Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut

  • Jin, Hee-Eun (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Choi, Jae-Chul (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Lim, Yong Taik (SKKU Advanced Institute of Nanotechnology, School of Chemical Engineering, Sungkyunkwan University) ;
  • Sung, Moon-Hee (Department of Bio and Fermentation Convergence Technology, Kookmin University)
  • Received : 2016.11.07
  • Accepted : 2016.12.07
  • Published : 2017.02.28
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Abstract

Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In this study, we investigated the effect of poly-gamma-glutamate (${\gamma}-PGA$) as a prebiotic on the gut microbiota of mice and the organ distributions of ${\gamma}-PGA$ in mice. Pyrosequencing analysis for 16S rRNA genes of bacteria indicated that oral administration of ${\gamma}-PGA$ increased the abundance of Lactobacillales while reducing the abundance of Clostridiales in murine guts. It is suggested that oral administration of ${\gamma}-PGA$ can be helpful for modulating the gut microbiota as a prebiotic.

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