Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Efficacy of Half Dose House Dust Mites-Specific Immunotherapy on Canine Atopic Dermatitis

  • Park, Jeong-Ho (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Lee, Wang-Hui (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Park, Seong-Jun (College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungnam National University)
  • Received : 2014.10.16
  • Accepted : 2017.01.19
  • Published : 2017.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to prove that the hypothesis of half dose (HD) allergen-specific immunotherapy (ASIT) in the treatment of canine atopic dermatitis (CAD) would result in a similar success rate compared to the standard dose (SD) ASIT. Clinical signs were evaluated using a third version of the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) prior to ASIT (day 0), at the end of induction (day 43), and at three month afterwards (day 90). Of the 18 atopic dogs, 12 dogs (SD group: 6; HD group: 6) had a good - excellent response to the house dust mites-specific immunotherapy. The efficacies of ASIT were 66.6% in both groups. The grades of reduction rate CADESI-03 were not different between two groups. Therefore, half dose protocol of house dust mites-specific immunotherapy is an effective and efficient method to treat CAD.

Keywords

References

  1. Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998; 102: 558-562. https://doi.org/10.1016/S0091-6749(98)70271-4
  2. Colombo S, Hill PB, Shaw DJ, Thoday KL. Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double - blinded, clinical study. Vet Dermatol 2005; 16: 162-170. https://doi.org/10.1111/j.1365-3164.2005.00453.x
  3. Day MJ. Immune-mediated skin disease. In: Immunology of the dog and cat, 2nd ed. London: Manson. 2008: 122-135.
  4. DeBoer DJ, Hillier A. The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol 2001; 81: 271-276. https://doi.org/10.1016/S0165-2427(01)00312-9
  5. Ewan PW, Alexander MM, Snape C, Ind PW, Agrell B, Dreborg S. Effective hyposensitization in allergic rhinitis using a potent partially purified extract of house dust mite. Clin Allergy 1988; 18: 501-508. https://doi.org/10.1111/j.1365-2222.1988.tb02900.x
  6. Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 2010; 21: 23-31. https://doi.org/10.1111/j.1365-3164.2009.00758.x
  7. Garfield RA. Injection immunotherapy in the treatment of canine atopic dermatitis: comparison 3 protocols. Proceedings of the 9th Annual AAVD and ACVD Meeting. Montreal, Canada. 1992: 7-8.
  8. Griffin CE, Hillier A. The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Vet Immunol Immunopathol 2001; 81: 363-383. https://doi.org/10.1016/S0165-2427(01)00348-8
  9. Halliwell R. Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol 2006; 114: 207-208. https://doi.org/10.1016/j.vetimm.2006.08.013
  10. Hill PB, DeBoer DJ. The ACVD task force on canine atopic dermatitis (IV): environmental allergens. Vet Immunol Immunopathol 2001; 81: 169-186. https://doi.org/10.1016/S0165-2427(01)00298-7
  11. Hillier A, DeBoer DJ. The ACVD task force on canine atopic dermatitis (XVII): intradermal testing. Vet Immunol Immunopathol 2001; 81: 208-304.
  12. Nuttall TJ, Thoday KL, van den Broek AH, Jackson HA, Sture GH, Halliwell RE. Retrospective survey of allergen immunotherapy in canine atopy. Vet Rec 1998; 143: 139-142. https://doi.org/10.1136/vr.143.5.139
  13. Olaguibel JM, Tabar AI, Garcia BE, Martin S, Rico P. Long-term immunotherapy with an optimal maintenance dose of a standardized Dermatophagoides pteronyssinus extract in asthmatic patients. J Investig Allergol Clin Immunol 1999; 9: 110-116.
  14. Olivry T, Mueller RS. Evidence-based veterinary dermatology: a systemic review of the pharmaco-therapy of canine atopic dermatitis. Vet Dermatol 2003; 14: 121-146. https://doi.org/10.1046/j.1365-3164.2003.00335.x
  15. Olivry T, Marsella R, Iwasaki T, Mueller R. Validation of CADESI-03, severity scales for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol 2007; 18: 78-86. https://doi.org/10.1111/j.1365-3164.2007.00569.x
  16. Olsen OT, Larsen KR, Jacobsen L, Svendsen UG. A 1 - year, placebo - controlled, double - blind house - dust - mite immunotherapy study in asthmatic adults. Allergy 1997; 52: 853-859. https://doi.org/10.1111/j.1398-9995.1997.tb02157.x
  17. Park S, Ohya F, Yamashita K, Nishifuji K, Iwasaki T. Comparison of response to immunotherapy by intradermal skin test and antigen - specific IgE in canine atopy. J Vet Med Sci 2000; 62: 983-988. https://doi.org/10.1292/jvms.62.983
  18. Reedy LM, Miller WH, Willemse T. Immunotherapy. In: Allergic Skin Diseases of Dogs and Cats, 2nd ed. Philadelphia: WB Saunders. 1997: 116-149.
  19. Rosser EJ. Aqueous hyposensitization in the treatment of canine atopic dermatitis: a retrospective study of 100 cases. In: Advances in Veterinary Dermatology, Vol. 3. Butterworths 1998; 169-176.
  20. Scott DW, Miller WH, Griffin CE. Skin immune system and allergic skin disease. In: Muller and Kirk's Small Animal Dermatology, 6th ed. Philadelphia: WB Saunders. 2001: 543-601.
  21. Song KH, Lee JY, Liu J, Lee SE, Park SJ and Kim DH. Prevalence of causative allergens on canine atopic dermatitis in Daejeon area. J Vet Clin 2005; 22: 26-30.
  22. Wagner R. A retrospective survey of hyposensitisation therapy using low concentrations of alum - precipitated allergen. Proceedings of the 15th ESVD SCVD Congress. Maastricht, the Netherlands 1998: 167.
  23. Willemse T. Atopic skin disease: a review and a reconsideration of diagnostic criteria. J Small Anim Pract 1986; 27: 771-778. https://doi.org/10.1111/j.1748-5827.1986.tb02119.x
  24. Willemse T, Bardagi M, Carlotti DN, Ferrer L, Fondati A, Fontaine J, Leistra M, Noli C, Ordeix L, Scarampella F, Schleifer S, Sinke J, Roosje P. Dermatophagoides farinae -specific immunotherapy in atopic dogs with hypersensitivity to multiple allergen: A randomized, double blind, placebo -controlled study. Vet J 2009; 180: 337-342. https://doi.org/10.1016/j.tvjl.2008.01.004
  25. Youn HY, Kang HS, Bhang DH, Kim MK and Hwang CY. Allergens causing atopic diseases in canine. J Vet Sci 2002; 3: 335-341.

Cited by

  1. A proposed medication score for long‐term trials of treatment of canine atopic dermatitis sensu lato vol.188, pp.5, 2021, https://doi.org/10.1002/vetr.19