Journal of Nutrition and Health

  • 제50권6호
  • /
  • Pages.595-602
  • /
  • 2017
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지
DOI QR코드

DOI QR Code

The impact of malnutrition on survival in patients with gynecologic cancer undergoing chemotherapy

  • Nho, Ju-Hee (College of Nursing, Chonbuk National University) ;
  • Kwon, Yong Soon (Department of Obstetrics and Gynecology, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Jo, Seongil (Department of Statistics (Institute of Applied Statistics), Chonbuk National University)
  • 투고 : 2017.08.23
  • 심사 : 2017.10.10
  • 발행 : 2017.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Malnutrition is a major concern in patients with gynecologic cancer receiving chemotherapy. The aim of this study was to evaluate the prognostic significance of malnutrition in patients with gynecologic cancer undergoing chemotherapy. Methods: A prospective, observational study was conducted on a total of 99 subjects who were treated at a tertiary hospital in Korea. Data regarding demographic, clinical, nutritional, and psychological characteristics at baseline and survival were obtained. Results: Performance status, nutritional status, depression, and annual income were significantly different between survivors and non-survivors. Multivariate Cox modeling after adjusting for other factors showed that a malnourished status in patients with gynecologic cancer undergoing chemotherapy was a significant and independent negative influencing factor for survival. Conclusion: These findings provide evidence that adequate nutritional assessment and intervention may assist in improving survival in patients with gynecologic cancer undergoing chemotherapy.

키워드

참고문헌

  1. American Cancer Society. Cancer facts & figures 2014. Atlanta (GA): American Cancer Society; 2014.
  2. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2014. Sejong: Ministry of Health and Welfare; 2016.
  3. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1990; 38(3): 352-357. https://doi.org/10.1016/0090-8258(90)90072-S
  4. Japan Society of Obstetrics and Gynecology, the Japanese Pathological Society, Japan Radiological Society. The general rules for clinical and pathological management of uterine cervical cancer. Tokyo: Kanehara Shuppan Kabushiki Kaisha; 1987.
  5. Chida Y, Hamer M, Wardle J, Steptoe A. Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol 2008; 5(8): 466-475. https://doi.org/10.1038/ncponc1134
  6. Falagas ME, Zarkadoulia EA, Ioannidou EN, Peppas G, Christodoulou C, Rafailidis PI. The effect of psychosocial factors on breast cancer outcome: a systematic review. Breast Cancer Res 2007; 9(4): R44. https://doi.org/10.1186/bcr1744
  7. Pasquini M, Biondi M. Depression in cancer patients: a critical review. Clin Pract Epidemiol Ment Health 2007; 3: 2. https://doi.org/10.1186/1745-0179-3-2
  8. Lehto US, Ojanen M, Dyba T, Aromaa A, Kellokumpu-Lehtinen P. Baseline psychosocial predictors of survival in localised breast cancer. Br J Cancer 2006; 94(9): 1245-1252. https://doi.org/10.1038/sj.bjc.6603091
  9. Hess LM, Barakat R, Tian C, Ozols RF, Alberts DS. Weight change during chemotherapy as a potential prognostic factor for stage III epithelial ovarian carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2007; 107(2): 260-265. https://doi.org/10.1016/j.ygyno.2007.06.010
  10. Gupta D, Lammersfeld CA, Vashi PG, Dahlk SL, Lis CG. Can subjective global assessment of nutritional status predict survival in ovarian cancer? J Ovarian Res 2008; 1(1): 5. https://doi.org/10.1186/1757-2215-1-5
  11. Barrera R. Nutritional support in cancer patients. JPEN J Parenter Enteral Nutr 2002; 26(5 Suppl): S63-S71. https://doi.org/10.1177/014860710202600516
  12. Nho JH, Kim SR, Kang GS, Kwon YS. Relationships among malnutrition, depression and quality of life in patients with gynecologic cancer receiving chemotherapy. Korean J Women Health Nurs 2014; 20(2): 117-125. https://doi.org/10.4069/kjwhn.2014.20.2.117
  13. Laky B, Janda M, Bauer J, Vavra C, Cleghorn G, Obermair A. Malnutrition among gynaecological cancer patients. Eur J Clin Nutr 2007; 61(5): 642-646. https://doi.org/10.1038/sj.ejcn.1602540
  14. Bauer J, Capra S, Ferguson M. Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer. Eur J Clin Nutr 2002; 56(8): 779-785. https://doi.org/10.1038/sj.ejcn.1601412
  15. Beck AT. Depression: clinical, experimental, and theoretical aspects. New York (NY): Hoeber; 1967.
  16. Lee YH, Song JY. A study of the reliability and the validity of the BDI, SDS, and MMPI-D scales. Korean J Clin Psychol 1991; 10(1): 98-113.
  17. Jo SA, Park MH, Jo I, Ryu SH, Han C. Usefulness of Beck Depression Inventory (BDI) in the Korean elderly population. Int J Geriatr Psychiatry 2007; 22(3): 218-223. https://doi.org/10.1002/gps.1664
  18. Kil SY, Oh WO, Koo BJ, Suk MH. Relationship between depression and health-related quality of life in older Korean patients with chronic obstructive pulmonary disease. J Clin Nurs 2010; 19(9-10): 1307-1314. https://doi.org/10.1111/j.1365-2702.2009.03053.x
  19. R Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2017.
  20. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974; 19(6): 716-723. https://doi.org/10.1109/TAC.1974.1100705
  21. Chan JK, Tian C, Monk BJ, Herzog T, Kapp DS, Bell J, Young RC; Gynecologic Oncology Group. Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer 2008; 112(10): 2202-2210. https://doi.org/10.1002/cncr.23390
  22. Chi DS, Liao JB, Leon LF, Venkatraman ES, Hensley ML, Bhaskaran D, Hoskins WJ. Identification of prognostic factors in advanced epithelial ovarian carcinoma. Gynecol Oncol 2001; 82(3): 532-537. https://doi.org/10.1006/gyno.2001.6328
  23. Winter WE 3rd, Maxwell GL, Tian C, Carlson JW, Ozols RF, Rose PG, Markman M, Armstrong DK, Muggia F, McGuire WP; Gynecologic Oncology Group Study. Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007; 25(24): 3621-3627. https://doi.org/10.1200/JCO.2006.10.2517
  24. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hutterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Muhlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC. ESPEN guidelines on nutrition in cancer patients. Clin Nutr 2017; 36(1): 11-48. https://doi.org/10.1016/j.clnu.2016.07.015
  25. Capra S, Ferguson M, Ried K. Cancer: impact of nutrition intervention outcome--nutrition issues for patients. Nutrition 2001; 17(9): 769-772. https://doi.org/10.1016/S0899-9007(01)00632-3
  26. Grant M, Kravits K. Symptoms and their impact on nutrition. Semin Oncol Nurs 2000; 16(2): 113-121. https://doi.org/10.1053/on.2000.5738
  27. Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 2005; 9 Suppl 2: S51-S63. https://doi.org/10.1016/j.ejon.2005.09.007
  28. Garssen B, Goodkin K. On the role of immunological factors as mediators between psychosocial factors and cancer progression. Psychiatry Res 1999; 85(1): 51-61. https://doi.org/10.1016/S0165-1781(99)00008-6
  29. Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol 2002; 13(7): 1087-1093. https://doi.org/10.1093/annonc/mdf187
  30. Scott HR, McMillan DC, Forrest LM, Brown DJ, McArdle CS, Milroy R. The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer. Br J Cancer 2002; 87(3): 264-267. https://doi.org/10.1038/sj.bjc.6600466
  31. Subramanian S, Chen A. Treatment patterns and survival among low-income medicaid patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg 2013; 139(5): 489-495. https://doi.org/10.1001/jamaoto.2013.2549
  32. Cykert S, Dilworth-Anderson P, Monroe MH, Walker P, McGuire FR, Corbie-Smith G, Edwards LJ, Bunton AJ. Factors associated with decisions to undergo surgery among patients with newly diagnosed early-stage lung cancer. JAMA 2010; 303(23): 2368-2376. https://doi.org/10.1001/jama.2010.793
  33. McCann J, Artinian V, Duhaime L, Lewis JW Jr, Kvale PA, DiGiovine B. Evaluation of the causes for racial disparity in surgical treatment of early stage lung cancer. Chest 2005; 128(5): 3440-3446. https://doi.org/10.1378/chest.128.5.3440