Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Hepatoprotective Effect of Blue Honeysuckle on Rat Hypothyroidism

  • Lee, Woo-Yeol (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Yi, Seong-Joon (Department of Veterinary Anatomy, College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Sungho (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Hong-Tae (Veterinary Service Laboratory, Busan Metropolitan City Institute of Health and Environment) ;
  • Lim, Mee-Kyung (School of Healthcare and Biotechnology, Kyungwoon University) ;
  • Lee, Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
  • Received : 2017.09.12
  • Accepted : 2017.12.13
  • Published : 2017.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study was to determine whether blue honeysuckle lyophilized concentrated powder (BH) has positive effects on hypothyroidism and related liver damage in propylthiouracil-induced Hypothyroidism. Levothyroxine (LT4)-treated group was administrated by intraperitoneal injection with LT4, while BH or Flos Lonicerae lyophilized aqueous extract (LF)-treated groups were orally administrated for 42 days which two weeks pri or to PTU injection. The changes in organ weight, serum AST & ALT, serum lipid level, liver defense system were measured and the histopathology of the liver was observed. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism-related liver damages through the enhance antioxidant defense system.

Keywords

References

  1. Amin A, Hamza AA. Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation. Toxicology 2005; 208: 367-375. https://doi.org/10.1016/j.tox.2004.11.039
  2. Das K, Chainy GB. Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. Biochim Biophys Acta 2001; 1537: 1-13. https://doi.org/10.1016/S0925-4439(01)00048-5
  3. Devdhar M, Ousman YH, Burman KD. Hypothyroidism. Endocrinol Metab Clin North Am 2007; 36: 595-615, v. https://doi.org/10.1016/j.ecl.2007.04.008
  4. Dory L, Roheim PS. Rat plasma lipoproteins and apolipoproteins in experimental hypothyroidism. J Lipid Res 1981; 22: 287-296.
  5. Feng X, Jiang Y, Meltzer P, Yen PM. Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Mol Endocrinol 2000; 14: 947-955. https://doi.org/10.1210/mend.14.7.0470
  6. Frost PH, Havel RJ. Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy. Am J Cardiol 1998; 81: 26b-31b. https://doi.org/10.1016/S0002-9149(98)00034-4
  7. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 2002; 13: 572-584. https://doi.org/10.1016/S0955-2863(02)00208-5
  8. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995; 155: 381-386. https://doi.org/10.1001/archinte.1995.00430040053006
  9. Ito M, Arishima T, Kudo T, Nishihara E, Ohye H, Kubota S, Fukata S, Amino N, Kuma K, Sasaki I, Hiraiwa T, Hanafusa T, Takamatsu J, Miyauchi A. Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients. J Clin Endocrinol Metab 2007; 92: 608-611. https://doi.org/10.1210/jc.2006-1605
  10. Jung YS, Kim SJ, Kwon DY, Ahn CW, Kim YS, Choi DW, Kim YC. Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism. Food Chem Toxicol 2013; 62: 292-298. https://doi.org/10.1016/j.fct.2013.08.049
  11. Jurikova T, Rop O, Mlcek J, Sochor J, Balla S, Szekeres L, Hegedusova A, Hubalek J, Adam V, Kizek R. Phenolic Profile of Edible Honeysuckle Berries (Genus Lonicera) and Their Biological Effects. Molecules 2012; 17: 61-79.
  12. Laycock MA, Pascuzzi RM. The neuromuscular effects of hypothyroidism. Semin Neurol 1991; 11: 288-294. https://doi.org/10.1055/s-2008-1041234
  13. Palikova I, Valentova K, Oborna I, Ulrichova J. Protectivity of blue honeysuckle extract against oxidative human endothelial cells and rat hepatocyte damage. J Agric Food Chem 2009; 57: 6584-6589. https://doi.org/10.1021/jf9003994
  14. Sarandol E, Tas S, Dirican M, Serdar Z. Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation. Cell Biochem Funct 2005; 23: 1-8. https://doi.org/10.1002/cbf.1119
  15. Subudhi U, Das K, Paital B, Bhanja S, Chainy GBN. Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats. Life Sci 2009; 84: 372-379. https://doi.org/10.1016/j.lfs.2008.12.024
  16. Subudhi U, Das K, Paital B, Bhanja S, Chainy GBN. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem Biol Interact 2008; 173: 105-114. https://doi.org/10.1016/j.cbi.2008.02.005
  17. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004; 291: 228-238. https://doi.org/10.1001/jama.291.2.228
  18. Wang L, Chen L, Tan Y, Wei J, Chang Y, Jin T, Zhu H. Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter. Lipids Health Dis 2013; 12: 34. https://doi.org/10.1186/1476-511X-12-34
  19. Williams KV, Nayak S, Becker D, Reyes J, Burmeister LA. Fifty years of experience with propylthiouracil-associated hepatotoxicity: what have we learned? J Clin Endocrinol Metab 1997; 82: 1727-1733.
  20. Wu S, He X, Wu X, Qin S, He J, Zhang S, Hou D-X. Inhibitory effects of blue honeysuckle (Lonicera caerulea L) on adjuvant-induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects. Journal of Functional Foods 2015; 17: 514-523. https://doi.org/10.1016/j.jff.2015.06.007