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The Korea Contents Association (한국콘텐츠학회)
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The Effectiveness of Volumetric Modulated arc Radiotherapy to Treat Patients with Metastatic Spinal Tumors

  • Park, Hyo-Kuk (Department of Radiation Oncology Yonsei Cancer Center) ;
  • Kim, Sungchul (Department of Radiation Oncology Yonsei Cancer Center)
  • Received : 2017.06.08
  • Accepted : 2017.12.22
  • Published : 2017.12.28
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Abstract

Among the possible stereotactic body radiation therapy (SBRT) modalities used to treat patients with metastatic spinal tumors, this study compared Cyberknife, tomotherapy, and volumetric modulated arc radiotherapy (VMAT). We established treatment plans for each of them modality and quantitatively analyzed the dose evaluation factors of the dose-volume histogram (DVH) for all spinal bones, focusing on the tumor and spinal cord, in order to examine the usefulness of VMAT. For the treatment planning dose, the mean dose ($D_{max}$) and $D_{5%}$ showed statistical differences in the target dose, but no difference was shown in the spinal cord dose. For the DVH indices, tomotherapy showed the best performance was the best in terms of uniformity index, while VMAT showed better performance was better than the other two modalities in terms of the conformity index and the dose gradient index. VMAT had a much shorter treatment time than Cyberknife and tomotherapy. These findings suggest that VMAT FFF is the most effective therapy for SBRT of patients with metastatic spinal tumors for whom a high dose of radiation is prescribed.

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References

  1. R. Lewis Wright, "Surgical Treatment for Metastatic Spinal Tumor," Ann Surg, vol. 157, no. 2, 1963, pp. 227-231. https://doi.org/10.1097/00000658-196302000-00008
  2. K. A. Ahmed, M. C. Stauder, R. C. Miller, H. J. Bauer, P. S. Rose, K. R. Olivier, P. D. Brown, D. H. Brinkmann, and N. N. Laack, "Stereotactic Body Radiation Therapy in Spinal Metastases," Int J Radiat Oncol BiolPhys, vol. 82, no. 5, 2012, pp. 803-809. https://doi.org/10.1016/j.ijrobp.2010.12.014
  3. S. Schipani, W. Wen, J. Y. Jin, J. K. Kim, and S. Ryu, "Spine Radiosurgery: A dosimetric analysis in 124 patients who recived 18Gy," Int J Radiat Oncol BiolPhys, vol. 84, no. 5, 2012, pp. 571-576
  4. S. H. Benedict, K. M. Yenice, D. Followill, J. M. Galvin, W. Hinson, B. Kavanagh, P. Keall, M. Lovelock, S. Meeks, L. Papiez, T. Purdie, R. Sadangopan, M. C. Schell, B. Salter, D. J. Schlesinger, A. S. Shiu, T. Solberg, D. Y. Song, V. Stieber, R. Timmerman, W. A. Tome, D. Verellen, L. Wang, and F. Yin, "Stereotactic body radiation therapy: The report of AAPM Task 101," Med Phys, vol. 8, no. 37, 2010, pp. 1-24.
  5. S. Ryu, F. F. Yin J. Rock, J. Zhu, A. Chu, E. Kaqan, L. Rogers, M. Ajlouni, M. Rosenblum, and J. H. Kim, "Image Guided and Intensity Modulated Radiosurgery for Patients with Spinal Metastasis," Cancer, vol. 8, no. 97, 2003, pp. 2013-2018.
  6. M. S. Kim, K. C. Keum, J. H. Cha, J. H. Kim, J. S. Seong, C. G. Lee, K. C. Nam, and W. S. Koom, "Stereotactic body radiotherapy with helical tomotherapy for pain palliation in spine metastasis," Technol Cancer Res Treat, vol. 12, no. 4, 2013, pp. 363-370. https://doi.org/10.7785/tcrt.2012.500329
  7. Q. J. Wu, S. Yoo, J. P. Kirkpatrick, D. Thongphiew, and F. F. Yin, "Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment," Int J Radiat Oncol Biol Phys, vol. 75, no. 5, 2009, pp. 1596-604. https://doi.org/10.1016/j.ijrobp.2009.05.005
  8. A. Fogliata, J. Fleckenstein, F. Schneider, M. Pachoud, S. Ghandour, H. Krauss, G. Reqqiori, A. Stravato, F. Lohr, M. Scorsetti, and L. Cozzi, "Flattening filter free beams from True Beam and Versa HD units: Evaluation of the parameters for quality assurance," Medical physics, vol. 43, no. 1, 2016, pp. 205-212 . https://doi.org/10.1118/1.4938060
  9. P. Navarria, A. M. Ascolese, P. Mancosu, F. Alonqi, E. Clerici, A. Tozzi, C. Iftode, G. Reggiori, S. Tomatis, M. Infante, M. Alloisio, A. Testori, A. Fogliata, L. Cozzi, E. Morenghi and M. Scorsetti, "Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) to treat patients with medically inoperable early stage non small cell lung cancer (NSCLC)," Radiother Oncol, vol. 107, no. 3, 2013, pp. 414-418. https://doi.org/10.1016/j.radonc.2013.04.016
  10. J. Kang, J. Lee, and D. J. Lee, "Calculation of Dose Distribution for SBRT Patient Using Geant4 Simulation Code," Progess in Medical Physics, vol. 26, no. 1, 2015, pp. 36-41. https://doi.org/10.14316/pmp.2015.26.1.36
  11. Y. Kang, C. S. Kay, S. H. Son, B. O. Choi, J. Jung, H. Shin, C. S. Kay, S. H. Son, M. H. Kim, J. Seo, and G. W. Lee, "Dosimetric comparison of stereotactic body radiotherapy for spinal metastasis in cyberknife and helical tomotherapy," Journal of the Korean Physical Society, vol. 61, no. 12, 2012, pp. 2049-2053. https://doi.org/10.3938/jkps.61.2049
  12. K. Slosarek, W. Osewski, A. Grzadziel, M. Radwan, L. Dolla, M. Szlag, and M. Stapor-Fudzinska, "Integral dose: Comparison between four techniques for prostate radiotherapy," Rep Pract Oncol Radiother, vol. 20, no. 2, 2014, pp. 99-103. https://doi.org/10.1016/j.rpor.2014.10.010