한국군사과학기술학회지 (Journal of the Korea Institute of Military Science and Technology)

  • 제20권6호
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  • Pages.781-787
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  • 2017
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  • 1598-9127(pISSN)
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  • 2636-0640(eISSN)
한국군사과학기술학회 (The Korea Institute of Military Science and Technology)
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이차 아민으로부터 트리클로로아세토니트릴을 사용한 테트라졸 유도체의 새로운 합성법

A New Method for Synthesizing Tetrazoles from Secondary Amines using Trichloroacetonitrile

  • 오수진 (국방과학연구소 제4기술연구본부)
  • Oh, Su-Jin (The 4th Research and Development Institute, Agency for Defense Development)
  • 투고 : 2017.08.17
  • 심사 : 2017.11.24
  • 발행 : 2017.12.05
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초록

A new method for synthesizing the tetrazole derivatives from secondary amines through cyanation/tetrazolation has been developed. Trichloroacetonitrile is used as the cyano source to synthesize N-nitrile instead of highly toxic and expensive cyanogen bromide. In this protocol, the reaction of secondary amines with various substituents proceed smoothly, and the desired tetrazole derivatives are obtained directly in fair to high yields without isolation of intermediate cyanamides.

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참고문헌

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