Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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The change aspects between testosterone and cytokines by castration in Hanwoo cattle

한우에서 거세에 의한 Testosterone 결핍이 사이토카인의 변화에 미치는 영향 연구

  • Kim, Seong Bum (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Cho, Ara (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Choe, Changyong (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Jung, Younghun (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Yoo, Jae Gyu (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Kim, Eunju (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration) ;
  • Do, Yoon Jung (Animal diseases & Biosecurity Team, National Institute of Animal Science, Rural Development Administration)
  • 김성범 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 조아라 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 최창용 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 정영훈 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 류재규 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 김은주 (농촌진흥청 국립축산과학원 가축질병방역팀) ;
  • 도윤정 (농촌진흥청 국립축산과학원 가축질병방역팀)
  • Received : 2017.09.28
  • Accepted : 2017.11.17
  • Published : 2017.12.30
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Abstract

The purpose of this study is to determine the changes of cytokines and immune cells in blood in castrated Hanwoo. The cytokine production and the number of immune cells were determined by collecting blood from jugular vein before castration and on 1, 7, and 28 days then after. Results of the hematological test showed that the number of leukocyte tend to increase after castration, and it significantly decreased on day 7 and day 28 (P<0.05). Lymphocytes decreased significantly on day 1 and 7 (P<0.05), and then recovered as in neutrophils on day 28. The levels of serum testosterone, TNF-a, IL-6, and anti-inflammatory IL-10 significantly decreased (P<0.05) after castration. There was also a decrease in IL-2, $IFN-{\gamma}$, and IL-4 but showed no significant difference when compared to intact ones. These results suggest that testosterone-deficiency does not affect the number of immune cells in blood, but has a close relationship with cytokine production.

Keywords

References

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