Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Antioxidative Effect of Ethanol Extract on Arctium lappa root in Streptozotocin Induced Diabetic Rats

우엉 뿌리 에탄올 추출물이 Streptozotocin으로 유발된 당뇨 흰쥐의 항산화에 미치는 영향

  • Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
  • 김옥경 (대진대학교 자연과학대학 식품영양학과)
  • Received : 2016.07.13
  • Accepted : 2016.09.02
  • Published : 2016.09.30
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Abstract

This study was carried to investigate the antioxidative effect of ethanol extract of Arctium lappa(Al) root in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg.body wight(b.w) dissolved in citrate buffer. The ethanol extract of Al root was orally administrated once a day for 7 days at a dose of 1,000mg/kg.b.w. The contents of malondialdehyde(MDA) and activities of catalase (CAT), glutathione peroxidase(GSH-Px) were significantly decreased(p<0.05) in Al treated group compared to the those of STZ-control group. The content of glutathione(GSH) and activity of glutathione-s-transferase(GST) was significantly increased(p<0.05). These results indicated that ethanol extract of Al root would have antioxidative effect in STZ-induced diabetic rats.

Streptozotocin(STZ)을 45mg/kg, body weight(b.w)의 용량으로 흰쥐의 미정맥에 투여 한 후 유발된 당뇨 흰쥐에게 우엉 뿌리 에탄올 추출물을 1일 1회 7일간 1,000mg/kg,bw의 용량으로 투여하고 항산화작용에 관여하는 glutathione-s-transferase(GST), catalase(CAT), glutathioneperoxidase (GSH-Px)활성과 malondialdehyde(MDA)와 glutathione(GSH) 함량을 측정한 결과 우엉 뿌리 에탄올 추추물 투여군에서 MDA 함량, CAT와 GSH-Px 활성 등의 유의적인 감소(p<0.05)를, GSH 함량과 GST 활성은 유의적인 증가(p<0.05)를 나타내었다. 이와 같이 우엉 뿌리 에탄올 추출물이 항산화 개선효과를 갖는 유효성분을 함유하고 있음을 알 수 있었다.

Keywords

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