Journal of Dairy Science and Biotechnology

  • 제34권3호
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  • Pages.165-172
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  • 2016
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  • 2733-4554(pISSN)
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  • 2733-4562(eISSN)
한국낙농식품응용생물학회 (Korean Society of Dairy Science and Biotechnology)
권호 표지

Kefir를 이용하여 다양한 Cancer 생성 예방 및 치료에 관한 연구

Beneficial Effects of Kefir in Preventing and Treating Human Cancers

  • 김동현 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 천정환 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 김현숙 (한양대학교 생활과학대학 식품영양학과) ;
  • 이수경 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 김홍석 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 임진혁 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 송광영 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 강일병 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 김영지 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 정다나 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 박진형 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 장호석 (건국대학교 수의과대학 식품안전건강연구소) ;
  • 서건호 (건국대학교 수의과대학 식품안전건강연구소)
  • Kim, Dong-Hyeon (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Chon, Jung-Whan (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hyunsook (Dept. of Food & Nutrition, College of Human Ecology, Hanyang University) ;
  • Lee, Soo-Kyung (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hong-Seok (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Yim, Jin-Hyuk (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Song, Kwang-Young (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Il-Byung (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Young-Ji (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Jeong, Dana (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Park, Jin-Hyeong (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Jang, Ho-Seok (Center for One Health, College of Veterinary Medicine, Konkuk University) ;
  • Seo, Kun-Ho (Center for One Health, College of Veterinary Medicine, Konkuk University)
  • 투고 : 2016.07.05
  • 심사 : 2016.08.07
  • 발행 : 2016.09.30
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초록

Kefir, originating from Caucasus, is an acidic, alcoholic fermented milk product with little acidic taste and a creamy consistency. It is recognized in having beneficial effects infor the prevention and treatment of cancer. For example, Kefir has possesses a chemopreventative effect on carcinogenesis. There has recently been a strong focus on fermented milk foods containing a mixture of several functional organic substances and various probiotic microorganisms. Hence, the purpose of this review paper was to evaluate the scientific evidence for the effects of kefir on cancer prevention and treatment. Some of we analyzed and summarized data-relating to the effects of kefir on cancer. The cacers that kefir has an effect on are as follows: colon cancer, breast cancer, leukemia, sarcoma, skin cancer, gastric cancer. This review suggests that (1) kefir could be associated with cancer prevention, (2) kefir has beneficial effects in cancer treatment, and (3) kefir has various bioactive components including peptides, polysaccharides and sphingolipids, which contribute tofor itsthese anti-cancer properties. Furthermore, furthermore, studies were performed in order to obtain as to get the scientific evidence of kefir's anticancer activity: (1) improved protective effectiveness in vivo (human subjects or animal model), (2) isolation and identification of various bioactive components, and (3) mechanisms associated with beneficial effects.

키워드

참고문헌

  1. Altay, F., Karbancioglu-Guler, F., Daskaya-Dikmen, C. and Heperkan, D. 2013. A review on traditional Turkish fermented non-alcoholic beverages: Microbiota, fermentation process and quality characteristics. Int. J. Food Microbiol. 167:44-56. https://doi.org/10.1016/j.ijfoodmicro.2013.06.016
  2. Cevikbas, A., Yemni, E., Ezzedenn, F. W., Yardimici, T., Cevikbas, U. and Stohs S. 1994. Antitumoural antibacterial and antifungal activities of kefir and kefir grain. Phytother Res. 8:78-82. https://doi.org/10.1002/ptr.2650080205
  3. Chen, C., Chan, H. M. and Kubow, S. 2007. Kefir extracts suppress in vitro proliferation of estrogen-dependent human breast cancer cells but not normal mammary epithelial cells. J. Med. Food 10:416-422. https://doi.org/10.1089/jmf.2006.236
  4. Chen, Z., Shi, J., Yang, X., Nan, B., Liu, Y. and Wang, Z. 2015. Chemical and physical characteristics and antioxidant activities of the exopolysaccharide produced by Tibetan kefir grains during milk fermentation. Int. Dairy J. 43:15-21. https://doi.org/10.1016/j.idairyj.2014.10.004
  5. de Menezes, R. F., Bergmann, A. and Thuler, L. C. 2013. Alcohol consumption and risk of cancer: A systematic literature review. Asian Pac. J. Cancer Prev. 14:4965-4972. https://doi.org/10.7314/APJCP.2013.14.9.4965
  6. de Moreno de LeBlanc, A., Matar, C., Farnworth, E. and Perdigon, G. 2006. Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir. Cytokine 34:1-8. https://doi.org/10.1016/j.cyto.2006.03.008
  7. de Moreno de LeBlanc, A. and Perdigon, G. 2010. The application of probiotic fermented milks in cancer and intestinal inflammation. Proc. Nutr. Soc. 69:421-428. https://doi.org/10.1017/S002966511000159X
  8. Dresch, P., MN, D. A., Rosam, K., Grienke, U., Rollinger, J. M. and Peintner, U. 2015. Fungal strain matters: Colony growth and bioactivity of the European medicinal polypores and. AMB Express 5:4. https://doi.org/10.1186/s13568-014-0093-0
  9. Furuya, H., Shimizu, Y. and Kawamori, T. 2011. Sphingolipids in cancer. Cancer Metastasis Rev. 30:567-576. https://doi.org/10.1007/s10555-011-9304-1
  10. Gao, J., Gu, F., Abdella, N. H., Ruan, H. and He, G. 2012. Investigation on culturable microflora in Tibetan kefir grains from different areas of China. J. Food Sci. 77:425-433. https://doi.org/10.1111/j.1750-3841.2012.02805.x
  11. Gao, J., Gu, F., Ruan, H., Chen, Q., He, J. and He, G. 2013. Induction of apoptosis of gastric cancer cells SGC7901 in vitro by a cell-free fraction of Tibetan kefir. Int. Dairy J. 30:14-18. https://doi.org/10.1016/j.idairyj.2012.11.011
  12. Garrote, G. L., Abraham, A. G. and De Antoni, G. L. 2010. "Microbial interactions in kefir: A natural probiotic drink," in Biotechnology of lactic acid bacteria, eds F. Mozzi, R. R. Raya and G. M. Vignolo (Ames, IO: Wiley-Blackwell), 327-340.
  13. Glei, M., Hofmann, T., Kuster, K., Hollmann, J., Lindhauer, M. G. and PoolZobel, B. L. 2006. Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J. Agric. Food Chem. 54:2088-2095. https://doi.org/10.1021/jf052768e
  14. Grishina, A., Kulikova, I., Alieva, L., Dodson, A., Rowland, I. and Jin, J. 2011. Antigenotoxic effect of kefir and ayran supernatants on fecal water-induced DNA damage in human colon cells. Nutr. Cancer 63:73-79.
  15. Han, Y., Wen, J., Zhou, T. and Fan, G. 2015. Chemical fingerprinting of Gardenia jasminoides Ellis by HPLCDAD-ESI-MS combined with chemometrics methods. Food Chem. 188:648-657. https://doi.org/10.1016/j.foodchem.2015.05.039
  16. Jianzhong, Z., Xiaoli, L., Hanhu, J. and Mingsheng, D. 2009. Analysis of the microflora in Tibetan kefir grains using denaturing gradient gel electrophoresis. Food Microbiol. 26:770-775. https://doi.org/10.1016/j.fm.2009.04.009
  17. Kabak, B. and Dobson, A. D. 2011. An introduction to the traditional fermented foods and beverages of Turkey. Crit. Rev. Food Sci. Nutr. 51:248-260. https://doi.org/10.1080/10408390903569640
  18. Key, T. J., Schatzkin, A., Willett, W. C., Allen, N. E., Spencer, E. A. and Travis, R. C. 2004. Diet, nutrition and the prevention of cancer. Public Health Nutr. 7:187-200.
  19. Khoury, N., El-Hayek, S., Tarras, O., El-Sabban, M., El-Sibai, M. and Rizk, S. 2014. Kefir exhibits antiproliferative and proapoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion. Int. J. Oncol. 45:2117-2127. https://doi.org/10.3892/ijo.2014.2635
  20. Larsson, S. C., Andersson, S. O., Johansson, J. E. and Wolk, A. 2008. Cultured milk, yogurt and dairy intake in relation to bladder cancer risk in a prospective study of Swedish women and men. Am. J. Clin. Nutr. 88:1083-1087. https://doi.org/10.1093/ajcn/88.4.1083
  21. Liu, J. R., Wang, S. Y., Lin, Y. Y. and Lin, C. W. 2002. Antitumor activity of milk kefir and soy milk kefir in tumor-bearing mice. Nutr. Cancer 44:183-187. https://doi.org/10.1207/S15327914NC4402_10
  22. Lopitz-Otsoa, F., Rementeria, A., Elguezabal, N. and Garaizar, J. 2006. Kefir: A symbiotic symbiotic yeasts-bacteria community with alleged healthy capabilities. Rev. Iberoa m. Micol. 23:67-74. https://doi.org/10.1016/S1130-1406(06)70016-X
  23. Maalouf, K., Baydoun, E. and Rizk, S. 2011. Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes. Cancer Manag. Res. 3:39-47.
  24. Murofushi, M., Mizuguchi, J., Aibara, K. and Matuhasi, T. 1986. Immunopotentiative effect of polysaccharide from kefir grain, KGF-C, administered orally in mice. Immunopharmacology 12:29-35. https://doi.org/10.1016/0162-3109(86)90049-4
  25. Nagira, T., Narisawa, J., Teruya, K., Katakura, Y., Shim, S. Y., Kusumoto, K., Tokumaru, S., Tokumaru, K., Barnes, D. W. and Shirahata, S. 2002. Suppression of UVC-induced cell damage and enhancement of DNA repair by the fermented milk, kefir. Cytotechnology 40:125-137. https://doi.org/10.1023/A:1023984304610
  26. Osada, K., Nagira, K., Teruya, K., Tachibana, H., Shirahata, S. and Murakami, H. 1993. Enhancement of interferonbeta production with sphingomyelin from fermented milk. Biotherapy 7:115-123. https://doi.org/10.1007/BF01877735
  27. Pepe, G., Tenore, G. C., Mastrocinque, R., Stusio, P. and Campiglia, P. 2013. Potential anticarcinogenic peptides from bovine milk. J. Amino Acids 2013:93980.
  28. Prado, M. R., Blandon, L. M., Vandenberghe, L. P. S., Rodrigues, C., Castro, G. R., Thomaz-Soccol, V. and Soccol, C. R. 2015. Milk kefir: Composition, microbial cultures, biological activities and related products. Front Microbiol. 6:1177.
  29. Rafie, N., Golpour Hamedani, S., Ghiasvand, R. and Miraghajani, M. 2015. Kefir and caner: A systematic review of literatures. Arch. Iran Med. 18:852-857.
  30. Rimada, P. S. and Abraham, A. G. 2006. Effects of different fermentation parameters on quality characteristics of kefir. Int. Dairy J. 16:33-39. https://doi.org/10.1016/j.idairyj.2005.02.002
  31. Rizk, S., Maalouf, K. and Baydoun, E. 2009. The antiproliferative effect of kefir cell-free fraction on HuT-102 malignant T lymphocytes. Clin. Lymphoma. Myeloma. 9:S198-S203. https://doi.org/10.3816/CLM.2009.s.012
  32. Rodrigues, K. L., Caputo, L. R. G., Carvalho, J. C. T., Evangelista, J. and Schneedorf, J. M. 2005a. Antimicrobial and healing activity of kefir and kefiran extract. Int. J. Antimicrob. Agents 25:404-408. https://doi.org/10.1016/j.ijantimicag.2004.09.020
  33. Rodrigues, K. L., Carvalho, J. C. T. and Schneedorf, J. M. 2005b. Anti-inflammatory properties of kefir and its polysaccharide extract. Inflammopharmacology 13:485-492. https://doi.org/10.1163/156856005774649395
  34. Serafini, F., Turroni, P., Ruas-Madiedo, G. A., Lugli, C., Milani, S., Duranti, N., Zamboni, N., Bottacini, F., van Sinderen, D., Margolles, A. and Ventura, M. 2014. Kefir fermented milk and kefiran promote growth of Bifidobacterium bifidum PRL2010 and modulate its gene expression. Int. J. Food Microbiol. 178:50-59. https://doi.org/10.1016/j.ijfoodmicro.2014.02.024
  35. Shiomi, M., Sasaki, K., Murofushi, M. and Aibara, K. 1982. Antitumor activity in mice of orally administered polysaccharide from kefir grain. Jpn. J. Med. Sci. Biol. 35:75-80. https://doi.org/10.7883/yoken1952.35.75
  36. Soccol, C. R., Prado, M. R. M., Garcia, L. M. B., Rodrigues, C. and Medeiros, A. B. P. 2014. Current developments in probiotics. J. Microb. Biochem. Technol. 7:11-20.
  37. van't Veer, P., Dekker, J. M., Lamers, J. W., Kok, F. J., Schouten, E. G., Brants, H. A., Sturmans, F. and Hermus, R. J. 1989. Consumption of fermented milk products and breast cancer: A case-control study in The Netherlands. Cancer Res. 49:4020-4023.
  38. Wang, Y., Ahmed, Z., Feng, W., Li, C. and Song, S. 2008. Physicochemical properties of exopolysaccharide produced by Lactobacillus kefiranofaciens ZW3 isolated from Tibet kefir. Int. J. Biol. Macromol. 43:283-288. https://doi.org/10.1016/j.ijbiomac.2008.06.011
  39. Wong, J. M., de Souza, R., Kendall, C. W., Emam, A. and Jenkins, D. J. 2006. Colonic health: Fermentation and short chain fatty acids. J. Clin. Gastroenterol. 40:235-243. https://doi.org/10.1097/00004836-200603000-00015
  40. Zajsek, K., Kolar, M. and Gorsek, A. 2011. Characterisation of the exopolysaccharide kefiran produced by lactic acid bacteria entrapped within natural kefir grains. Int. J. Dairy Technol. 64:544-548. https://doi.org/10.1111/j.1471-0307.2011.00704.x