대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제2권1호
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  • Pages.56-60
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  • 2016
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  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
권호 표지
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DOI QR Code

Novel synthetic method for the preparation of α-iododaphnetin using benzyltrimethylammonium dichloroiodate

  • Kim, Taek-Soo (Radiation Instrumentation Research Division, Atomic Energy Research Institute) ;
  • Kim, Bo-Ram (Radiation Instrumentation Research Division, Atomic Energy Research Institute) ;
  • Park, Jeong Hoon (Radiation Instrumentation Research Division, Atomic Energy Research Institute) ;
  • Yang, Seung Dae (Radiation Instrumentation Research Division, Atomic Energy Research Institute)
  • 투고 : 2016.06.04
  • 심사 : 2016.06.19
  • 발행 : 2016.06.30
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초록

Benzyltrimethylammonium dichloroiodate in the presence of $ZnCl_2$ has been used for aromatic iodination of electron rich aromatic compounds. However, Baylis-Hillman type regioselective ${\alpha}$-iodination was carried out electronically rich coumarin compound under mild reaction condition with excellent chemical yield. Finally, $BBr_3$ demethylation gave ${\alpha}$-iododaphnetin.

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참고문헌

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