Cold Medications Aggravated Rhabdomyolysis Symptoms Induced by Building Construction Work and Strenuous Exercise: a Case Report

건축노동과 스트레스성 운동에 의한 횡문근융해증상을 악화시키는 감기약: 증례보고

  • Yoon, Hyonok (College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University) ;
  • Jang, Yoon Jin (College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University) ;
  • Park, Si Nae (College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University) ;
  • Choi, Eun Joo (College of Pharmacy, Chosun University) ;
  • Kim, Soo Wan (Division of Nephrology, Department of Internal Medicine, Chonnam National University Hospital and Medical School of Chonnam National University)
  • 윤현옥 (경상대학교 약학대학 및 약학연구소) ;
  • 장윤진 (경상대학교 약학대학 및 약학연구소) ;
  • 박시내 (경상대학교 약학대학 및 약학연구소) ;
  • 최은주 (조선대학교 약학대학) ;
  • 김수완 (전남대학교 의학전문대학원 및 전남대학교병원 신장내과)
  • Received : 2016.01.04
  • Accepted : 2016.07.05
  • Published : 2016.09.30

Abstract

A 21-year-old healthy Korean man worked on a building construction site every day for almost 2 months and exercised every day for 1 or 2 hours after working hard. He felt dizziness, nausea, and experienced vomiting and body aches immediately after exercise and immediately took cold medicines including acetaminophen, cimetidine, bepotastine, and Codenal? complex for the common cold symptoms for 2 days because he was scheduled to participate in navy training at that time. He complained of severe trapezius pain and aches in his left calf 3 days after joining the Navy training. Testing revealed creatine phosphokinase (CPK) 6260 U/L, myogloblin 176 mcg/L in the urine, liver enzymes increased, and oliguria, suggesting rhabdomyolysis. He recovered with intravenous fluids without any complications.

Keywords

References

  1. Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis:Pathophysiology and diagnosis. Eur J Intern Med 2007;18(2):90-100. https://doi.org/10.1016/j.ejim.2006.09.020
  2. Khan FY. Rhabdomyolysis: a review of the literature. Neth J Med 2009;67(9):272-83.
  3. Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. N Engl J Med 2009;361(1):62-72. https://doi.org/10.1056/NEJMra0801327
  4. Olerud JE, Homer LD, Carroll HW. Incidence of acute exertional rhabdomyolysis. Serum myoglobin and enzyme levels as indicators of muscle injury. Arch Intern Med 1976;136(6):692-7. https://doi.org/10.1001/archinte.1976.03630060044010
  5. Shintani S, Shiigai T, Tsukagoshi H. Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment. Eur Neurol 1991;31(6):396-8. https://doi.org/10.1159/000116702
  6. Bonnor R, Siddiqui M, Ahuja TS. Rhabdomyolysis associated with near-drowning. Am J Med Sci 1999;318(3):201-2. https://doi.org/10.1016/S0002-9629(15)40615-9
  7. Blanco JR, Zabalza M, Salcedo J, Echeverria L, Garcia A, Vallejo M. Rhabdomyolysis of infectious and noninfectious causes. South Med J 2002;95(5):542-4. https://doi.org/10.1097/00007611-200295050-00017
  8. Pesik NT, Otten EJ. Severe rhabdomyolysis following a viral illness: a case report and review of the literature. J Emerg Med 1996;14(4):425-8. https://doi.org/10.1016/0736-4679(96)00078-9
  9. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005;84(6):377-85. https://doi.org/10.1097/01.md.0000188565.48918.41
  10. Moneret-Vautrin DA, Morisset M, Humbert JC, et al. Acetaminopheninduced rhabdomyolysis. Allergy 1999; 54(10):1115-6. https://doi.org/10.1034/j.1398-9995.1999.00983.x
  11. Yang CC, Deng JF, Lin TJ. Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. Vet Hum Toxicol 2001;43(6):344-8.
  12. Tsang JS, Au WY. Cough mixture abuse and rhabdomyolysis. Hong Kong Med J 2012;18(1):68-9.
  13. Vendemiale G, Altomare E, Trizio T, et al. Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans. Am J Gastroenterol 1987;82(10):1031-4.
  14. Kim KG, Kim JH, Kim SM, et al. Clinical study of rhabdomyolysis developed after the training. Korean J Intern Med 2002;63(6):675-81.