생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권3호
  • /
  • Pages.280-286
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  • 2016
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

예쁜꼬마선충을 이용한 돼지감자의 수명 연장 효능

Lifespan Extending Effects of Helianthus tuberosus Linne in C. elegans

  • 이병주 (우석대학교 약학대학) ;
  • 윤영진 (우석대학교 약학대학) ;
  • 오종우 (우석대학교 약학대학) ;
  • 박지원 (우석대학교 약학대학) ;
  • 이현주 (우석대학교 약학대학) ;
  • 김용성 (우석대학교 약학대학) ;
  • 차동석 (우석대학교 약학대학) ;
  • 권진 (한국복지대학 의료보장구과) ;
  • 오찬호 (우석대학교 식품생명공학과) ;
  • 전훈 (우석대학교 약학대학)
  • 투고 : 2016.07.28
  • 심사 : 2016.09.21
  • 발행 : 2016.09.30
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초록

Helianthus tuberosus Linne (Compositae) has been widely used as a folk remedy to treat various ailments including fever, bleeding, fracture and contusion. This study was designed to elucidate the lifespan extending activities MeOH extract of the tubers of Helianthus tuberosus Linne (MHT) using Caenorhabditis elegans (C. elegans) model system. In the current study, we found that the lifespan of worms was significantly extended by MHT supplement, dose-dependently. MHT also provided robust protection against various stress environments such as osmotic, thermal and oxidative condition. In addition, elevated antioxidant enzyme activities by MHT resulted in attenuation of intracellular reactive oxygen spices (ROS) levels, suggesting antioxidant capacity of MHT might be associated with longevity properties. Herein, we showed that altered food intake and growth of worms were also involved in the MHT activity. Furthermore, MHT increased body movement in aged worms, indicating possible role for MHT in healthspan.

키워드

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