Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

Chemical Constituents from Leaves of Pileostegia viburnoides Hook.f.et Thoms

  • Li, Xiao Jun (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Liu, Zu Zhen (Hunan Society of Chinese Medicine) ;
  • Kim, Kwan-Woo (College of Pharmacy, Wonkwang University) ;
  • Wang, Xiang (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Li, Zhi (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Yook, Chang Soo (School of Pharmacy, KyungHee University) ;
  • Liu, Xiang Qian (School of Pharmacy, Hunan University of Chinese Medicine)
  • Received : 2015.10.26
  • Accepted : 2016.02.22
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Phytochemical investigation on the leaves of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3), epifriedelinol (4), canophyllal (5), stigmast-4-en-3-one (6), stigmasterol (7), (24R)-5A-stigmastane-3,6-dione (8), ursolic acid (9), pomolic acid (10), umbelliferone (11), 4-epifriedelin (12), n-octatriacontanol (13), ${\beta}$-amyrin (14), ${\alpha}$-amyrin (15), taraxerol (16), nonadecanol (17), friedelane (18), arachic acid (19), protocatechuic acid (20), n-pentatriacontanol (21), hexadecanoic acid (22), vincosamide (23), daucosterol (24), and skimming (25), respectively. To our best knowledge, compounds 1, 2, 12, 13, 17 - 19 and 21-23 were new within Saxifragaceae family. Compounds 15, 16, and 20 were produced from this genus for the first time. Compounds 4, 14 and 25 were first obtained from species P. viburnoides and compounds 3, 5 - 11, and 24 were achieved from the leaves of P. viburnoides for the first time. Furthermore, the anti-neuroinflammatory activity of these isolates was evaluated.

Keywords

References

  1. Cai, G. X.; Zhou, S.; Tan, G. B. Hunan Yaowuzhi: Hunan Science and Technology Press: Changsha, 2004, pp 3360-3361.
  2. Jin, J. D. China's Naturopathy 2001, 9, 41.
  3. Li, X. J.; Yuan, Y.; Li, Z.; Liu, X. Q. Chinese Traditional and Herbal Drugs 2014, 45, 1052-1055.
  4. Yuan, Y.; Liu, X. Q.; Liu, Z. Z.; Zou, Q. P.; Liu, H. Y.; Dai, L. Journal of Chinese Medicinal Materials 2011, 34, 1894-1897.
  5. Yang, D. D.; Liu, X. Q.; Liu, Z. Z.; Zou, Q. P.; Liu, H. Y.; Dai, L. Northwest Pharmaceutical Journal 2012, 27, 189-192.
  6. Pan, X. X.; Guo, J. S.; Guo, Z. Y.; Li, Z.; Nie, J. Lishizhen Medicine and Materia Medica Research 2012, 23, 1920-1921.
  7. Qin, L. H.; Zhong, H. M.; Chen, X. Y.; Wu, Y. F.; Li, Z.; Huang, K. Chinese Journal of Gerontology 2014, 34, 429-431.
  8. Titheradge, M. A. Methods Mol. Biol. 1998, 100, 83-91.
  9. Chang, C. W.; Wu, T. S.; Hsieh, Y. S.; Kuo, S. C.; Chao, P. D. J. Nat. Prod. 1999, 62, 327-328. https://doi.org/10.1021/np980313w
  10. Zhang, Q. J.; Yang, X. S.; Zhu, H. Y.; Hao, X. J. Journal of Guizhou University (Natural Sciences) 2006, 23, 270-271.
  11. Matsunaga, S.; Tanaka, R.; Akagi, M. Phytochemistry 1988, 27, 535-537. https://doi.org/10.1016/0031-9422(88)83136-4
  12. Leong, Y. W.; Harrison, L. J. Phytochemistry 1999, 50, 849-857. https://doi.org/10.1016/S0031-9422(98)00565-2
  13. Kundu, J. K.; Rouf, A. S.; Hossain, M. N.; Hasan, C. M.; Rashid, M. A. Fitoterapia 2000, 71, 577-579. https://doi.org/10.1016/S0367-326X(00)00191-X
  14. Patra, A.; Chaudhuri, S. K. Indian J. Chem. 1989, 28B, 376-380.
  15. Sun, L. L.; Zhong, Y.; Xia, H. M.; Zhou, Q.; Jia, L. V. Chin. Herb. Med. 2013, 5, 1-4.
  16. Chen, I. S.; Lin, Y. C.; Tsai, I. L.; Teng, C. M.; Ko, F. N.; Ishikawa, T.; Ishii, H. Phytochemistry 1995, 39, 1091-1097. https://doi.org/10.1016/0031-9422(95)00054-B
  17. He, Z.; Zhao, M.; Zong, Y. Y.; Cai, S. X.; Che, Z. T. Chinese Traditional and Herbal Drugs 2010, 41, 36-39.
  18. Tian, M. Y.; Peng, L. J.; Feng, T. T.; Chen, L.; Zhou, Y. Journal of Mountain Agriculture and Biology 2014, 33, 089-091.
  19. Yue, J. R.; Feng, D. Q.; Xu, Y. K. Nat. Prod. Res. 2015, 29, 1228-1234. https://doi.org/10.1080/14786419.2015.1023725
  20. Xu, W. Q.; Gong, X. J.; Zhou, X.; Mei, X. P.; Chen, B. B. Chinese Traditional and Herbal Drugs 2010, 41, 1056-1060.
  21. Ya, Q. K.; Lu, W. J.; Chen, J. Y.; Tan, X. Journal of Chinese Medicinal Materials 2010, 33, 1254-1256.
  22. Chen, Y.; Wei, H. C.; Wei, Z.; Zheng, X. R.; Zhang, L.; Zhou, Z. Lishizhen Medicine and Materia Medica Research 2012, 23, 1725-1726.
  23. Erdelmeier, C. A.; Wright, A. D.; Orjala, J.; Baumgartner, B.; Rali, T.; Sticher, O. Planta Med. 1991, 57, 149-152. https://doi.org/10.1055/s-2006-960052
  24. He, Y. Z.; Eric, K. O.; Sivoko, I. P.; Wang, L. N.; Naji, S. A. Chin. Herb. Med. 2014, 6, 76-79. https://doi.org/10.1016/S1674-6384(14)60012-5
  25. Petrul'ova-Poracka. V.; Repcak, M.; Vilkova, M.; Imrich, J. Food Chem. 2013, 141, 54-59. https://doi.org/10.1016/j.foodchem.2013.03.004

Cited by

  1. Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity vol.22, pp.4, 2016, https://doi.org/10.3390/molecules22040532
  2. Chemical Constituents from Stems of Pileostegia viburnoides vol.14, pp.1, 2016, https://doi.org/10.1177/1934578x1901400127
  3. Chemical Constituents of the Fruit Husk of Xanthoceras sorbifolia vol.56, pp.2, 2020, https://doi.org/10.1007/s10600-020-03020-3
  4. Highly Substituted Phenol Derivatives with Nitric Oxide Inhibitory Activities from the Deep-Sea-Derived Fungus Trichobotrys effuse FS524 vol.18, pp.3, 2016, https://doi.org/10.3390/md18030134
  5. Echinops taeckholmiana Amin: Optimization of a Tissue Culture Protocol, Biological Evaluation, and Chemical Profiling Using GC and LC-MS vol.6, pp.20, 2016, https://doi.org/10.1021/acsomega.1c00837