Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
권호 표지
DOI QR코드

DOI QR Code

A Study on the Relationship between Obesity Factors and NK Cell Activity in White-Collar Females

사무직 여성의 비만요인에 따른 NK세포 활성도 관계 연구

  • Sung, Hyun-Ho (Department of Clinical Laboratory Science, Dongnam Health University) ;
  • Song, Chang-Sub (Department of Biomedical Engineering, Seonam University) ;
  • Choi, Kwang-Mo (Department of Laboratory Medicine, Samsung Medical Center) ;
  • Park, Chang-Eun (Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul University)
  • 성현호 (동남보건대학교 임상병리과) ;
  • 송창섭 (서남대학교 의용공학과) ;
  • 최광모 (삼성서울병원 진단검사의학과) ;
  • 박창은 (남서울대학교 임상병리학과, 분자진단연구소)
  • Received : 2016.07.27
  • Accepted : 2016.09.04
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

An effective strategy for obesity intervention should include demographic, health-related, and work-related factors that are most relevant to the target population. Factors most strongly associated with obesity may differ for groups of individuals across industries or age categories. The purpose of this study was to provide current knowledge about the possible association between psychosocial job stress and immune parameters in blood. We assessed obesity-related parameters as well as the natural killer cell activity (NKCA) in female workers. There was a significant difference in the obesity-related blood parameters, i.e. fasting blood sugar level, according to age (p<0.05). Moreover, it showed a significant difference in NK cell activity between the obese and non-obese factor groups (p<0.05). Pearson correlation analysis demonstrated that NKCA was closely correlated with obesity related factors. In the future, it would have to study the biological changes which increase the activity of the immune factors to the immunological response.

효과적인 비만의 중재는 대상 인구에서 가장 관련성이 있는 인구통계학적 건강 관련 및 직무 관련 요인을 고려해야 한다. 가장 강력한 비만 관련 요인은 직업군 또는 연령 범주에서 다룰 수 있다. 이 연구의 목적은 심리적인 직무 스트레스와 면역관련 인자의 혈액분석의 상관성에 대한 최신지견을 제공하는 것이다. 우리는 여성 근로자의 비만 관련 매개 변수 뿐만 아니라 자연살해세포활성(NKCA)을 평가하였다. 비만과 관련된 혈당(p<0.05)은 연령에서 유의한 차이를 보였다. 또한, 비만군과 non-비만군에서는 NK 세포의 활성에 큰 차이를 보였다(p<0.05). 단계적 다중 회귀 분석에서 NKCA는 비만 관련 요인과 밀접한 상관성을 보였다. 향후에는 면역인자들의 활성도가 증가하는 생물학적 변화를 연구해야 할 것이다.

Keywords

References

  1. Heraclides A, Chandola T, Witte DR, Brunner EJ. Psychosocial stress at work doubles the risk of type 2 diabetes in middle-aged women: evidence from the Whitehall II study. Diabetes Care. 2009;32:2230-2510. https://doi.org/10.2337/dc09-0132
  2. Spruill TM. Chronic psychosocial stress and hypertension. Curr Hypertens Rep. 2010;12:10-16. https://doi.org/10.1007/s11906-009-0084-8
  3. Aboa-Eboule C, Brisson C, Maunsell E, Masse B, Bourbonnais R, Vezina M, et al. Job strain and risk of acute recurrent coronary heart disease events. JAMA. 2007;298:1652-1660. https://doi.org/10.1001/jama.298.14.1652
  4. Chandola T, Brunner E, Marmot M. Chronic stress at work and the metabolic syndrome: prospective study. BMJ. 2006;332:521-525.
  5. McNeely E. The consequences of job stress for nurses' health. Time for a check-up. Nurs Outlook. 2005;53:291-299. https://doi.org/10.1016/j.outlook.2005.10.001
  6. Nakata A, Takahashi M, Irie M, Swanson NG. Job satisfaction is associated with elevated natural killer cell immunity among healthy white-collar employees. Brain Behav Immun. 2010;24:1268-1275. https://doi.org/10.1016/j.bbi.2010.05.004
  7. Lee KM, Kang D, Yoon K, Kim SY, Kim H, Yoon HS, et al. A pilot study on the association between job stress and repeated measures of immunological biomarkers in female nurses. Int Arch Occup Environ Health. 2010;83:779-789. https://doi.org/10.1007/s00420-010-0544-0
  8. Eckel RH, Alberti K, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2010;375:181-183. https://doi.org/10.1016/S0140-6736(09)61794-3
  9. World Health Organization. The Asia-Pacific perspective: Redefining obesity and its treatment 2000. [cited 2016 August 31]. Available from: http://www.wpro.who.int/nutrition/docudocs/Redefiningobesity.pdf
  10. Friedman EM, Lawrence DA. Environmental stress mediates changes in neuroimmunological interactions. Toxicol Sci. 2002;67:4-10. https://doi.org/10.1093/toxsci/67.1.4
  11. Kawamura N1, Kim Y, Asukai N. Suppression of cellular immunity in men with a past history of posttraumatic stress disorder. Am J Psychiatry. 2001;158:484-486. https://doi.org/10.1176/appi.ajp.158.3.484
  12. Zorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A, et al. The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun. 2001;15:199-226. https://doi.org/10.1006/brbi.2000.0597
  13. Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56 (bright) subset. Blood. 2001;97:3146-3151. https://doi.org/10.1182/blood.V97.10.3146
  14. Schroder K1, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004;75:163-189. https://doi.org/10.1189/jlb.0603252
  15. Morikawa Y, Kitaoka-Higashiguchi K, Tanimoto C, Hayashi M, Oketani R, Miura K, et al. A cross-sectional study on the relationship of job stress with natural killer cell activity and natural killer cell subsets among healthy nurses. J Occup Health. 2005;47:378-383. https://doi.org/10.1539/joh.47.378
  16. Lang J, Ochsmann E, Kraus T, Lang JW. Psychosocial work stressors as antecedents of musculoskeletal problems: a systematic review and meta-analysis of stability-adjusted longitudinal studies. Soc Sci Med. 2012;75:1163-1174. https://doi.org/10.1016/j.socscimed.2012.04.015
  17. Goodson NJ, Smith BH, Hocking LJ, McGilchrist MM, Dominiczak AF, Morris A, et al. Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: results from a cross-sectional general population study. Pain. 2013;154:1595-1602. https://doi.org/10.1016/j.pain.2013.04.043
  18. Herr RM, Bosch JA, Loerbroks A, van Vianen AE, Jarczok MN, Fischer JE, et al. Three job stress models and their relationship with musculoskeletal pain in blue-collar and white-collar workers. J Psychosom Res. 2015;79:340-347. https://doi.org/10.1016/j.jpsychores.2015.08.001
  19. Centers for Disease Control and Prevention. Social ecological model 2013 [cited 2016 August 31]. Available from: http://www.cdc.gov/obesity/health_equity/addressingtheissue.html
  20. Tchicaya A, Lorentz N. Socioeconomic inequality and obesity prevalence trends in Luxembourg, 1995-2007. BMC Res Notes. 2012;5:467. doi: 10.1186/1756-0500-5-467.
  21. Shin KA, Kim HY, Kim NJ. Association between exercise capacity and cardiovascular risk factors among obesity types in adult Man. Korean J Clin Lab Sci. 2013;45:96-101.
  22. Schulte PA, Wagner GR, Ostry A, Blanciforti LA, Cutlip RG, Krajnak KM, et al. Work, obesity, and occupational safety and health. Am J Public Health. 2007;97:428-436. https://doi.org/10.2105/AJPH.2006.086900
  23. Luckhaupt SE, Cohen MA, Li J, Calvert GM. Prevalence of obesity among U.S. workers and associations with occupational factors. Am J Prev Med. 2014;46:237-248. https://doi.org/10.1016/j.amepre.2013.11.002
  24. Garza JL, Dugan AG, Faghri PD, Gorin AA, Huedo-Medina TB, Kenny AM, et al. Demographic, health-related, and work-related factors associated with body mass index and body fat percentage among workers at six Connecticut manufacturing companies across different age groups: a cohort study. BMC Obes. 2015;20:43. doi: 10.1186/s40608-015-0073-1.
  25. Park KT, Kim IS, Yoo SC, Yoon JS, Ahn TH, Lee JH. et al. Relationship between serum uric acid, abdominal obesity, and waist circumference in Korean. Korean J Clin Lab Sci. 2012;44:39-45.

Cited by

  1. 임상병리사의 직무스트레스의 수준에 따른 하위영역의 실태조사 vol.49, pp.1, 2017, https://doi.org/10.15324/kjcls.2017.49.1.48
  2. 생쥐에서 치자시탕(梔子豉湯)의 항스트레스 효과에 대한 연구 vol.28, pp.3, 2016, https://doi.org/10.7231/jon.2017.28.3.183
  3. 경남지역 일부 근로자들의 비만에 영향을 미치는 요인 vol.24, pp.2, 2021, https://doi.org/10.21289/ksic.2021.24.2.135