Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice

  • Titlow, William B. (Sander-Brown Center on Aging, College of Medicine, University of Kentucky) ;
  • Waqas, Muhammad (Department of Pharmacy, College of Pharmacy, Hanyang University) ;
  • Lee, Jihyun (Department of Pharmacy, College of Pharmacy, Hanyang University) ;
  • Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Lee, Sang Yeol (Department of Life Science, Gachon University) ;
  • Kim, Dae-Hwan (Institute of Pharmaceutical Technology, Hanyang University) ;
  • Ryou, Chongsuk (Sander-Brown Center on Aging, College of Medicine, University of Kentucky)
  • Received : 2016.01.22
  • Accepted : 2016.05.23
  • Published : 2016.09.28
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Abstract

Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.

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References

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