Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

  • Lee, Hyunjong (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Lee, Won Woo (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Park, So Yeon (Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Sang Eun (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • Received : 2015.09.08
  • Accepted : 2015.12.28
  • Published : 2016.04.01
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Abstract

Objective: The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis. Materials and Methods: We retrospectively enrolled 6 thyroid cancer patients (age = $44.7{\pm}9.8$ years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients. Results: Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05). Conclusion: Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.

Keywords

Acknowledgement

Supported by : Seoul National University College of Medicine, National Research Foundation of Korea (NRF)

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