Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Hypertriglyceridemia and Cardiovascular Diseases: Revisited

  • Han, Seung Hwan (Department of Cardiology, Gachon University Gil Medical Center) ;
  • Nicholls, Stephen J (Department of Cardiology, South Australian Health and Medical Research Institute, University of Adelaide) ;
  • Sakuma, Ichiro (Department of Cardiovascular Medinine, Hokko Memorial Clinic) ;
  • Zhao, Dong (Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing An Zhen Hospital, Capital Medical University) ;
  • Koh, Kwang Kon (Department of Cardiology, Gachon University Gil Medical Center)
  • Received : 2016.01.06
  • Accepted : 2016.01.26
  • Published : 2016.03.30
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Abstract

Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.

Keywords

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