DOI QR코드

DOI QR Code

Staining Characteristics of Mast Cell Tumor in a Hedgehog

  • Lee, Jong-Won (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Han, Mi-Na (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Gon-Hyung (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Chang, Dong-Woo (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Na, Ki-Jeong (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University)
  • 투고 : 2016.04.04
  • 심사 : 2016.06.24
  • 발행 : 2016.08.31

초록

A 2-year old female African hedgehog (Atelerix albiventris) weighing 645 grams was presented with a well circumscribed mass in the subcutaneous of the left shoulder. It measured $2{\times}2cm$ in size and had a hard texture. There were no clinical signs. In a fine-needle aspiration (FNA) cytological evaluation, mast cells were identified with Wright-Giemsa stain. Mast cell tumor was confirmed and characterized by surgical sampling and histopathological evaluation. Four stains (hematoxylin-eosin, toluidine blue, periodic acid-Schiff, and Safranin O) were examined in order to find an applicable stain for a mast cell tumor histopathological evaluation in hedgehog. This case showed that periodic acid-Schiff and toluidine blue staining were the most useful for assessment of a mast cell tumor in a hedgehog.

키워드

참고문헌

  1. Bostock DE. Neoplasms of the skin and subcutaneous tissues in dogs and cats. British Vet J 1986; 142: 1-19. https://doi.org/10.1016/0007-1935(86)90002-3
  2. Galli SJ, Maurer M, Lantz CS. Mast cells as sentinels of innate immunity. Curr Opin Immunol 1999; 11: 53-59. https://doi.org/10.1016/S0952-7915(99)80010-7
  3. Galli SJ, Nakae S. Mast cells to the defense. Nature Immunol 2003; 4: 1160-1162. https://doi.org/10.1038/ni1203-1160
  4. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nature Immunol 2005; 6: 135-142. https://doi.org/10.1038/ni1158
  5. Galli SJ, Wershil BK. The two faces of the mast cell. Nature 1996; 381: 21-22. https://doi.org/10.1038/381021a0
  6. Govier SM. Principles of treatment for mast cell tumors. Clin Tech Small Anim Pract 2003; 18: 103-106. https://doi.org/10.1053/svms.2003.36624
  7. Ko KR, Hong KH, Kim JH. Basal cell carcinoma in a domestic hedgehog. J Vet Clin 2015; 32: 548-550. https://doi.org/10.17555/jvc.2015.12.32.6.548
  8. London CA, Galli SJ, Yuuki T, Hu ZQ, Helfand SC, Geissler EN. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Experi Hematol 1999; 27: 689-697. https://doi.org/10.1016/S0301-472X(98)00075-7
  9. Macy DW. Canine mast cell tumors. Veterinary Clinics of North America: Small Ani Pract 1985; 15: 783-803. https://doi.org/10.1016/S0195-5616(85)50036-4
  10. Raymond JT, Garner MM: Spontaneous tumors in captive African hedgehogs (Atelerix albiventris): A retrospective study. J Comp Pathol 2001; 124: 128-133. https://doi.org/10.1053/jcpa.2000.0441
  11. Raymond JT, White MR, Janovitz EB. Malignant mast cell tumor in an African hedgehog (Atelerix albiventris). J Wildlife Dise 1997; 33: 140-142. https://doi.org/10.7589/0090-3558-33.1.140
  12. Simoes JPC, Schoning P. Canine mast cell tumors: a comparison of staining techniques. J Vet Diagn Invest 1994; 6: 458-465. https://doi.org/10.1177/104063879400600410
  13. Tams TR, Macy DW. Canine mast cell tumors. Compend Contin Educ Vet 1981; 17: 869-878.
  14. Wedemeyer J, Tsai M, Galli SJ. Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 2000; 12: 624-631. https://doi.org/10.1016/S0952-7915(00)00154-0
  15. Welle MM, Bley CR, Howard J, Rfenacht S. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 2008; 19: 321-339. https://doi.org/10.1111/j.1365-3164.2008.00694.x