Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Venous angioma may be associated with epilepsy in children

  • Kim, Bo Ryung (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Lee, Yun Jin (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Nam, Sang Ook (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Park, Kyung Hee (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine)
  • Received : 2016.04.27
  • Accepted : 2016.07.20
  • Published : 2016.08.15
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: Venous angioma (VA) is the most common congenital abnormality of the intracranial vasculature. This study aimed to investigate the relationship between VA and epilepsy and to identify the characteristics of children with VA and epilepsy. Methods: The records of all patients aged less than 18 years who underwent brain magnetic resonance imaging (MRI) at Pusan National University Hospital were retrospectively reviewed. Patients with isolated VA and patients with normal MRI were compared in terms of the prevalence of epilepsy. Results: In total, 2,385 pediatric patients who underwent brain MRI were enrolled. Isolated VA was identified in 26 patients (VA group). Among the patients with normal MRI findings, 225 age- and sexmatched patients to the VA-group were assigned to the control group. Nine patients in the VA group (9 of 26, 34.6%) and 27 patients in the control group (26 of 225, 11.5%; P<0.001) had epilepsy. In the VA group, 20 patients (76.9%) had the VA in the cerebral hemispheres, and 6 patients (23.1%) had the VA in the brainstem and cerebellum. The latter showed a higher prevalence of epilepsy (5 of 6, 83.3%) than the former (4 of 20, 20.0%; P=0.004). Among the nine patients who had epilepsy with VA, patients whose VA involved the brainstem and cerebellum showed a significantly higher frequency of abnormal Electroencephalographic findings than patients whose VA involved the cerebral hemispheres (P=0.016). Conclusion: VA, especially in the brainstem and cerebellum, might be associated with epilepsy.

Keywords

References

  1. Kraemer DL, Awad IA. Vascular malformations and epilepsy: clinical considerations and basic mechanisms. Epilepsia 1994;35 Suppl 6:S30-43.
  2. Lasjaunias P. Vascular diseases in neonates, infants and children: interventional neuroradiology management. New York: Springer-Verlag; 1997.
  3. Truwit CL. Venous angioma of the brain: history, significance, and imaging findings. AJR Am J Roentgenol 1992;159:1299-307. https://doi.org/10.2214/ajr.159.6.1442406
  4. Sarwar M, McCormick WF. Intracerebral venous angioma. Case report and review. Arch Neurol 1978;35:323-5. https://doi.org/10.1001/archneur.1978.00500290069012
  5. Striano S, Nocerino C, Striano P, Boccella P, Meo R, Bilo L, et al. Venous angiomas and epilepsy. Neurol Sci 2000;21:151-5. https://doi.org/10.1007/s100720070090
  6. Lasjaunias P, Burrows P, Planet C. Developmental venous anomalies (DVA): the so-called venous angioma. Neurosurg Rev 1986;9:233-42. https://doi.org/10.1007/BF01743138
  7. Pereira VM, Geibprasert S, Krings T, Aurboonyawat T, Ozanne A, Toulgoat F, et al. Pathomechanisms of symptomatic developmental venous anomalies. Stroke 2008;39:3201-15. https://doi.org/10.1161/STROKEAHA.108.521799
  8. Fujii M, Kitahara T, Moroi J, Kato S, Ito H. Temporal lobe epilepsy associated with cerebral venous angioma: case report. Neurol Med Chir (Tokyo) 1998;38:413-6. https://doi.org/10.2176/nmc.38.413
  9. Topper R, Jurgens E, Reul J, Thron A. Clinical significance of intracranial developmental venous anomalies. J Neurol N eurosurg Psychiatry 1999;67:234-8 https://doi.org/10.1136/jnnp.67.2.234
  10. Garner TB, Del Curling O Jr, Kelly DL Jr, Laster DW. The natural history of intracranial venous angiomas. J Neurosurg 1991;75:715-22. https://doi.org/10.3171/jns.1991.75.5.0715
  11. Gumus A, Yildirim SV, Kizilkilic O, Cengiz N, Cemil T. Case report: seizures in a child caused by a large venous angioma. J Child Neurol 2007;22:787-9. https://doi.org/10.1177/0883073807304056
  12. Harvey AS, Jayakar P, Duchowny M, Resnick T, Prats A, Altman N, et al. Hemifacial seizures and cerebellar ganglioglioma: an epilepsy syndrome of infancy with seizures of cerebellar origin. Ann Neurol 1996;40:91-8. https://doi.org/10.1002/ana.410400115
  13. Chae JH, Kim SK, Wang KC, Kim KJ, Hwang YS, Cho BK. Hemifacial seizure of cerebellar ganglioglioma origin: seizure control by tumor resection. Epilepsia 2001;42:1204-7.
  14. Norden AD, Blumenfeld H. The role of subcortical structures in human epilepsy. Epilepsy Behav 2002;3:219-31. https://doi.org/10.1016/S1525-5050(02)00029-X
  15. Krauss GL, Koubeissi MZ. Cerebellar and thalamic stimulation treatment for epilepsy. Acta Neurochir Suppl 2007;97(Pt 2):347-56.
  16. Blumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, et al. Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures. Brain 2009;132(Pt 4):999-1012. https://doi.org/10.1093/brain/awp028

Cited by

  1. Prevalence of Developmental Venous Anomalies Increases With Age vol.48, pp.7, 2016, https://doi.org/10.1161/strokeaha.116.016145
  2. Surgically Treated Epilepsy due to Developmental Venous Anomaly of the Brain: Case Report and Review of the Literature vol.141, pp.None, 2016, https://doi.org/10.1016/j.wneu.2020.06.040