Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes

  • Kim, Eun-Hee (Department of Pediatrics, CHA Gangnam Medical Center, CHA University) ;
  • Ko, Tae-Sung (Division of Pediatric Neurology, Department of Pediatrics, Asan Medical Center Children's Hospital, Ulsan University College of Medicine)
  • 투고 : 2015.08.21
  • 심사 : 2015.11.16
  • 발행 : 2016.04.15
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초록

Cognitive impairment associated with childhood-onset epilepsy is an important consequence in the developing brain owing to its negative effects on neurodevelopmental and social outcomes. While the cause of cognitive impairment in epilepsy appears to be multifactorial, epilepsy-related factors such as type of epilepsy and underlying etiology, age at onset, frequency of seizures, duration of epilepsy, and its treatment are considered important. In recent studies, antecedent cognitive impairment before the first recognized seizure and microstructural and functional alteration of the brain at onset of epilepsy suggest the presence of a common neurobiological mechanism between epilepsy and cognitive comorbidity. However, the overall impact of cognitive comorbidity in children with epilepsy and the independent contribution of each of these factors to cognitive impairment have not been clearly delineated. This review article focuses on the significant contributors to cognitive impairment in children with epilepsy.

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참고문헌

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피인용 문헌

  1. APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures vol.98, pp.None, 2017, https://doi.org/10.1016/j.nbd.2016.11.002
  2. Embelin Protects Against Acute Pentylenetetrazole-Induced Seizures and Positively Modulates Cognitive Function in Adult Zebrafish vol.10, pp.None, 2016, https://doi.org/10.3389/fphar.2019.01249
  3. Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy vol.90, pp.None, 2019, https://doi.org/10.1016/j.yebeh.2018.11.011
  4. A new approach for assessing executive functions in everyday life, among adolescents with Genetic Generalised Epilepsies vol.30, pp.2, 2020, https://doi.org/10.1080/09602011.2018.1468272
  5. Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning vol.41, pp.3, 2016, https://doi.org/10.1007/s10072-019-04141-6
  6. Active avoidance learning in WAG/Rij rats with genetic predisposition to absence epilepsy vol.165, pp.None, 2020, https://doi.org/10.1016/j.brainresbull.2020.10.007
  7. Multiple-brain systems dynamically interact during tonic and phasic states to support language integrity in temporal lobe epilepsy vol.32, pp.None, 2016, https://doi.org/10.1016/j.nicl.2021.102861
  8. Results of the expert forum on the use of perampanel in adolescents with epilepsy in everyday clinical practice vol.12, pp.4, 2016, https://doi.org/10.17749/2077-8333/epi.par.con.2020.054
  9. Association of epileptiform brain activity and specific language impairment (SLI) in preschool children vol.57, pp.1, 2021, https://doi.org/10.1186/s41983-021-00269-5
  10. The interictal activities load and cognitive performance of children with typical absence epilepsy vol.57, pp.1, 2021, https://doi.org/10.1186/s41983-021-00299-z
  11. Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy vol.42, pp.17, 2021, https://doi.org/10.1002/hbm.25644
  12. Cognitive profile, psychopathological symptoms, and quality of life in newly diagnosed pediatric epilepsy: A six-month, naturalistic follow-up study vol.179, pp.None, 2022, https://doi.org/10.1016/j.eplepsyres.2021.106844