Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Improved axonal regeneration by Boyanghwano-tang treatment in mice given sciatic nerve injury

좌골신경 손상 모델에서 보양환오탕 처리에 의한 축삭 재생반응성 분석

  • Chang, In-Ae (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Ki-Joong (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University) ;
  • Namgung, Uk (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
  • Received : 2016.07.04
  • Accepted : 2016.08.01
  • Published : 2016.08.20
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Abstract

While axons in the peripheral nerve can regenerate and lead to functional recovery to a certain extent after injury, its efficacy varies depending on the severity and duration of the injury. Here, we investigated the effects of Boyanghwano-tang (BYHOT) treatment on the regenerative responses in the sciatic nerves after prolonged transection and coaptation surgery. In mice given crush injury, axonal regeneration was completed when analyzed 1 week later and did not show any difference in regenerative reponses in the distal portion of the nerve between saline- and BYHOT-treated groups. In animal models with transection and reconnection, axonal regeneration was markedly retarded compared to animals with crush injury. Regenerating axons were extended into the reconnected distal portion of the nerve more actively in animals treated with BYHOT than saline controls. Cdc2 protein was similarly induced in nerves with crush injury and with transection and recollection, and its level was lower in BYHOT-treated animal than saline control when measured 2 weeks after nerve reconnection. These results suggest that BYHOT may be useful to promote axonal regeneration in the peripheral nerve after severe injury.

Keywords

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