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Improved axonal regeneration by Boyanghwano-tang treatment in mice given sciatic nerve injury  

Chang, In-Ae (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
Kim, Ki-Joong (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
Namgung, Uk (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Haehwa Medicine / v.25, no.1, 2016 , pp. 99-108 More about this Journal
Abstract
While axons in the peripheral nerve can regenerate and lead to functional recovery to a certain extent after injury, its efficacy varies depending on the severity and duration of the injury. Here, we investigated the effects of Boyanghwano-tang (BYHOT) treatment on the regenerative responses in the sciatic nerves after prolonged transection and coaptation surgery. In mice given crush injury, axonal regeneration was completed when analyzed 1 week later and did not show any difference in regenerative reponses in the distal portion of the nerve between saline- and BYHOT-treated groups. In animal models with transection and reconnection, axonal regeneration was markedly retarded compared to animals with crush injury. Regenerating axons were extended into the reconnected distal portion of the nerve more actively in animals treated with BYHOT than saline controls. Cdc2 protein was similarly induced in nerves with crush injury and with transection and recollection, and its level was lower in BYHOT-treated animal than saline control when measured 2 weeks after nerve reconnection. These results suggest that BYHOT may be useful to promote axonal regeneration in the peripheral nerve after severe injury.
Keywords
Axonal regeneration; sciatic nerve; transection; crush injury; Schwann cell; mouse;
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