Communications for Statistical Applications and Methods

  • 제23권4호
  • /
  • Pages.287-296
  • /
  • 2016
  • /
  • 2287-7843(pISSN)
  • /
  • 2383-4757(eISSN)
한국통계학회 (The Korean Statistical Society)
권호 표지
DOI QR코드

DOI QR Code

Comparison of sequential estimation in response-adaptive designs with and without covariate-adjustment

  • Park, Eunsik (Department of Statistics, Chonnam National University)
  • 투고 : 2016.04.03
  • 심사 : 2016.07.21
  • 발행 : 2016.07.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Subjects on one side of the covariate population can be allocated to the inferior treatment when there is interaction between the covariate and treatment along with a response-adaptive (RA) design without covariate adjustment. An RA design allows a newly entered subject to have a better chance so that the subject is treated by a superior treatment based on cumulative information from previous subjects. A covariate-adjusted response-adaptive (CARA) is the same as RA design and additionally adjusts the allocation based on individual covariate information. A comparison has been made for the sequential estimation procedure with and without covariate adjustment to see how ignoring significantly interactive covariate affects the correct treatment allocation. Using logistic models, we present simulation results regarding the coverage probability of treatment effect, correct allocation, and stopping time.

키워드

참고문헌

  1. Bandyopadhyay U, Biswas A, and Bhattacharya R (2007). A covariate adjusted two-stage allocation design for binary responses in randomized clinical trials, Statistics in Medicine, 26, 4386-4399. https://doi.org/10.1002/sim.2869
  2. Chang YI and Park E (2013). Sequential estimation for covariate-adjusted response-adaptive designs, Journal of the Korean Statistical Society, 42, 105-116. https://doi.org/10.1016/j.jkss.2012.06.001
  3. Hu F and Rosenberger WF (2006). The Theory of the Response-Adaptive Randomization in Clinical Trials, Wiley Inter Science, London.
  4. McCullagh P and Nelder JA (1989). Generalized Linear Models (2nd ed), Chapman and Hall, London, UK.
  5. Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. (2009). Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer, New England Journal of Medicine, 360, 1408-1417. https://doi.org/10.1056/NEJMoa0805019
  6. Zelen M and Wei LJ (1995). Foreword. In N Flournoy and WF Rosenberger (Eds), Adaptive Designs, Institute of Mathematical Statistics, Hayward, CA.
  7. Zhang LX, Hu F, Cheung SH, and Chan WS (2007). Asymptotic properties of covariate-adjusted response-adaptive designs, Annals of Statistics, 35, 1166-1182. https://doi.org/10.1214/009053606000001424