The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
권호 표지
DOI QR코드

DOI QR Code

Comparisons of orthodontic root resorption under heavy and jiggling reciprocating forces during experimental tooth movement in a rat model

  • Hikida, Takuji (Department of Orthodontics, Nihon University School of Dentistry at Matsudo) ;
  • Yamaguchi, Masaru (Department of Orthodontics, Nihon University School of Dentistry at Matsudo) ;
  • Shimizu, Mami (Department of Orthodontics, Nihon University School of Dentistry at Matsudo) ;
  • Kikuta, Jun (Department of Orthodontics, Nihon University School of Dentistry at Matsudo) ;
  • Yoshino, Tomokazu (Department of Orthodontics, Nihon University School of Dentistry at Matsudo) ;
  • Kasai, Kazutaka (Department of Orthodontics, Nihon University School of Dentistry at Matsudo)
  • Received : 2015.09.02
  • Accepted : 2015.11.23
  • Published : 2016.07.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: Root mobility due to reciprocating movement of the tooth (jiggling) may exacerbate orthodontic root resorption (ORR). "Jiggling" describes mesiodistal or buccolingual movement of the roots of the teeth during orthodontic treatment. In the present study, buccolingual movement is described as "jiggling." We aimed to investigate the relationship between ORR and jiggling and to test for positive cell expression in odontoclasts in resorbed roots during experimental tooth movement (jiggling) in vivo. Methods: Male Wistar rats were divided into control, heavy force (HF), optimal force (OF), and jiggling force (JF) groups. The expression levels of cathepsin K, matrix metalloproteinase (MMP)-9 protein, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant 1 (CINC-1; an IL-8-related protein in rodents), receptor activator of nuclear factor ${\kappa}B$ ligand (RANKL), and osteoprotegerin protein in the dental root were determined using immunohistochemistry. Results: On day 21, a greater number of root resorption lacunae, which contained multinucleated odontoclasts, were observed in the palatal roots of rats in the JF group than in rats from other groups. Furthermore, there was a significant increase in the numbers of cathepsin K-positive and MMP-9-positive odontoclasts in the JF group on day 21. Immunoreactivities for IL-6, CINC-1, and RANKL were stronger in resorbed roots exposed to jiggling than in the other groups on day 21. Negative reactivity was observed in the controls. Conclusions: These results suggest that jiggling may induce ORR via inflammatory cytokine production during orthodontic tooth movement, and that jiggling may be a risk factor for ORR.

Keywords

References

  1. Kaley J, Phillips C. Factors related to root resorption in edgewise practice. Angle Orthod 1991;61:125-32.
  2. Malmgren O, Goldson L, Hill C, Orwin A, Petrini L, Lundberg M. Root resorption after orthodontic treatment of traumatized teeth. Am J Orthod 1982;82:487-91. https://doi.org/10.1016/0002-9416(82)90317-7
  3. Linge BO, Linge L. Apical root resorption in upper anterior teeth. Eur J Orthod 1983;5:173-83. https://doi.org/10.1093/ejo/5.3.173
  4. Owman-Moll P, Kurol J, Lundgren D. The effects of a four-fold increased orthodontic force magnitude on tooth movement and root resorptions. An intra-individual study in adolescents. Eur J Orthod 1996;18:287-94. https://doi.org/10.1093/ejo/18.3.287
  5. Owman-Moll P, Kurol J, Lundgren D. Effects of a doubled orthodontic force magnitude on tooth movement and root resorptions. An inter-individual study in adolescents. Eur J Orthod 1996;18:141-50. https://doi.org/10.1093/ejo/18.2.141
  6. Chan E, Darendeliler MA. Physical properties of root cementum: Part 5. Volumetric analysis of root resorption craters after application of light and heavy orthodontic forces. Am J Orthod Dentofacial Orthop 2005;127:186-95. https://doi.org/10.1016/j.ajodo.2003.11.026
  7. Brezniak N, Wasserstein A. Root resorption after orthodontic treatment: Part 2. Literature review. Am J Orthod Dentofacial Orthop 1993;103:138-46. https://doi.org/10.1016/S0889-5406(05)81763-9
  8. Mirabella AD, Artun J. Risk factors for apical root resorption of maxillary anterior teeth in adult orthodontic patients. Am J Orthod Dentofacial Orthop 1995;108:48-55. https://doi.org/10.1016/S0889-5406(95)70065-X
  9. Hayashi A, Hayashi H, Kawata T. Prevention of root resorption in hypofunctional teeth by occlusal function recovery. Angle Orthod 2015. doi:10.2319/012215-47.1. [Epub ahead of print]
  10. Nakano Y, Yamaguchi M, Fujita S, Asano M, Saito K, Kasai K. Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force. Eur J Orthod 2011;33:335-43. https://doi.org/10.1093/ejo/cjq068
  11. Kaku M, Sumi H, Shikata H, Kojima S, Motokawa M, Fujita T, et al. Effects of pulpectomy on the amount of root resorption during orthodontic tooth movement. J Endod 2014;40:372-8. https://doi.org/10.1016/j.joen.2013.11.027
  12. Gonzales C, Hotokezaka H, Yoshimatsu M, Yozgatian JH, Darendeliler MA, Yoshida N. Force magnitude and duration effects on amount of tooth movement and root resorption in the rat molar. Angle Orthod 2008;78:502-9. https://doi.org/10.2319/052007-240.1
  13. Kohno T, Matsumoto Y, Kanno Z, Warita H, Soma K. Experimental tooth movement under light orthodontic forces: rates of tooth movement and changes of the periodontium. J Orthod 2002;29:129-35. https://doi.org/10.1093/ortho/29.2.129
  14. Gameiro GH, Nouer DF, Pereira-Neto JS, de Araujo Magnani MB, de Andrade ED, Novaes PD, et al. Histological analysis of orthodontic root resorption in rats treated with the cyclooxygenase-2 (COX-2) inhibitor celecoxib. Orthod Craniofac Res 2008;11:156-61. https://doi.org/10.1111/j.1601-6343.2008.00424.x
  15. Eross E, Turk T, Elekdag-Turk S, Cakmak F, Jones AS, Vegh A, et al. Physical properties of root cementum: Part 25. Extent of root resorption after the application of light and heavy buccopalatal jiggling forces for 12 weeks: A microcomputed tomography study. Am J Orthod Dentofacial Orthop 2015;147:738-46. https://doi.org/10.1016/j.ajodo.2015.01.021
  16. Brudvik P, Rygh P. Non-clast cells start orthodontic root resorption in the periphery of hyalinized zones. Eur J Orthod 1993;15:467-80. https://doi.org/10.1093/ejo/15.6.467
  17. Brezniak N, Wasserstein A. Root resorption after orthodontic treatment: Part 1. Literature review. Am J Orthod Dentofacial Orthop 1993;103:62-6. https://doi.org/10.1016/0889-5406(93)70106-X
  18. Brudvik P, Rygh P. Root resorption beneath the main hyalinized zone. Eur J Orthod 1994;16:249-63. https://doi.org/10.1093/ejo/16.4.249
  19. Kurol J, Owman-Moll P. Hyalinization and root resorption during early orthodontic tooth movement in adolescents. Angle Orthod 1998;68:161-5.
  20. Kvam E. Scanning electron microscopy of tissue changes on the pressure surface of human premolars following tooth movement. Scand J Dent Res 1972;80:357-68.
  21. Rygh P. Ultrastructural cellular reactions in pressure zones of rat molar periodontium incident to orthodontic tooth movement. Acta Odontol Scand 1972;30:575-93. https://doi.org/10.3109/00016357209019790
  22. Ohashi M, Yamaguchi M, Hikida T, Kikuta J, Shimizu M, Goseki T, et al. Jiggling force induces orthodontic root resorption during tooth movement in rats. Int Oral-Med Sci 2015;14:13-20. https://doi.org/10.5466/ijoms.14.13
  23. Meikle MC. The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. Eur J Orthod 2006;28:221-40.
  24. Wucherpfennig AL, Li YP, Stetler-Stevenson WG, Rosenberg AE, Stashenko P. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J Bone Miner Res 1994;9:549-56.
  25. Oshiro T, Shibasaki Y, Martin TJ, Sasaki T. Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth. Anat Rec 2001;264:305-11. https://doi.org/10.1002/ar.1127
  26. Tsuchiya M, Akiba Y, Takahashi I, Sasano Y, Kashiwazaki J, Tsuchiya S, et al. Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar. Arch Histol Cytol 2008;71:89-100. https://doi.org/10.1679/aohc.71.89
  27. Asano M, Yamaguchi M, Nakajima R, Fujita S, Utsunomiya T, Yamamoto H, et al. IL-8 and MCP-1 induced by excessive orthodontic force mediates odontoclastogenesis in periodontal tissues. Oral Dis 2011;17:489-98. https://doi.org/10.1111/j.1601-0825.2010.01780.x
  28. Hayashi N, Yamaguchi M, Nakajima R, Utsunomiya T, Yamamoto H, Kasai K. T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces. Oral Dis 2012;18:375-88. https://doi.org/10.1111/j.1601-0825.2011.01886.x
  29. Kikuta J, Yamaguchi M, Shimizu M, Yoshino T, Kasai K. Notch signaling induces root resorption via RANKL and IL-6 from hPDL cells. J Dent Res 2015;94:140-7. https://doi.org/10.1177/0022034514555364
  30. Garlet TP, Coelho U, Repeke CE, Silva JS, Cunha Fde Q, Garlet GP. Differential expression of osteoblast and osteoclast chemmoatractants in compression and tension sides during orthodontic movement. Cytokine 2008;42:330-5. https://doi.org/10.1016/j.cyto.2008.03.003

Cited by

  1. Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 1: Relationship between root length and orthodontic tooth movement vol.87, pp.6, 2017, https://doi.org/10.2319/031317-188.1
  2. Caspase-mediated Apoptosis by Compressive Force Induces RANKL in Cementoblasts vol.16, pp.2, 2016, https://doi.org/10.5466/ijoms.16.31
  3. Expression of IL-34 in Root Resorption by Excessive Orthodontic Force vol.16, pp.1, 2017, https://doi.org/10.5466/ijoms.16.8
  4. Root resorption in orthodontic treatment with clear aligners: A systematic review and meta‐analysis vol.22, pp.4, 2016, https://doi.org/10.1111/ocr.12337
  5. Notch Signaling Response to Heavy Compression Force Induces Orthodontic Root Resorption via RANKL and IL-6 from Cementoblasts vol.18, pp.3, 2016, https://doi.org/10.5466/ijoms.18.287
  6. Is Inflammation a Friend or Foe for Orthodontic Treatment?: Inflammation in Orthodontically Induced Inflammatory Root Resorption and Accelerating Tooth Movement vol.22, pp.5, 2021, https://doi.org/10.3390/ijms22052388