DOI QR코드

DOI QR Code

Primary Squamous Cell Carcinoma of the Remnant Stomach after Subtotal Gastrectomy

  • Chang, Yeon Soo (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • Kim, Min Sung (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • Kim, Dong Hee (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • Park, Seulkee (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • You, Ji Young (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • Han, Joon Kil (Department of Surgery, Eulji Medical Center, Eulji University College of Medicine) ;
  • Kim, Seong Hwan (Department of Internal Medicine, Eulji Medical Center, Eulji University College of Medicine) ;
  • Lee, Ho Jung (Department of Pathology, Eulji Medical Center, Eulji University College of Medicine)
  • Received : 2016.05.11
  • Accepted : 2016.05.30
  • Published : 2016.06.30

Abstract

Primary squamous cell carcinoma (SCC) of the stomach is a very rare disease. However, the pathogenesis, clinical characteristics, and prognosis of gastric SCC are controversial and remain to be elucidated. Herein, we report a case of primary gastric SCC of the remnant stomach after subtotal gastrectomy. A 65-year-old man was admitted to our hospital due to epigastric discomfort and dizziness. He had undergone subtotal gastrectomy 40 years previously for gastric ulcer perforation. Endoscopy revealed a normal esophagus and a large mass in the remnant stomach. Abdominal computed tomography revealed enhanced wall thickening of the anastomotic site and suspected metachronous gastric cancer. Endoscopic biopsy revealed SCC. Total gastrectomy was performed with Roux-en-Y esophagojejunostomy. A 10-cm tumor was located at the remnant stomach just proximal to the previous area of anastomosis. Pathologic examination showed well-differentiated SCC extended into the subserosa without lymph node involvement (T3N0M0). The patient received adjuvant systemic chemotherapy with 6 cycles of 5-FU and cisplatin regimen, and he is still alive at the 54-month follow-up. According to the treatment principles of gastric cancer, early detection and radical surgical resection can improve the prognosis.

Keywords

References

  1. Gao S, Chen D, Huang L, Dai R, Shan Y. Primary squamous cell carcinoma of the stomach: a case report and literature review. Int J Clin Exp Pathol 2015;8:9667-9671.
  2. Ruck P, Wehrmann M, Campbell M, Horny HP, Breucha G, Kaiserling E. Squamous cell carcinoma of the gastric stump. A case report and review of the literature. Am J Surg Pathol 1989;13:317-324. https://doi.org/10.1097/00000478-198904000-00007
  3. Wegstapel H, Thomas WE. Squamous cell carcinoma of the stomach following gastric surgery. Br J Clin Pract 1990;44:736-737.
  4. Piper MH, Ross JM, Bever FN, Shartsis JM, Mohammadi D. Primary squamous cell carcinoma of a gastric remnant. Am J Gastroenterol 1991;86:1080-1082.
  5. Tokuhara K, Nakano T, Inoue K, Nakane Y, Kwon AH. Primary squamous cell carcinoma in the gastric remnant. Surg Today 2012;42:666-669. https://doi.org/10.1007/s00595-012-0144-6
  6. Boswell JT, Helwig EB. Squamous cell carcinoma and adenoacanthoma of the stomach. A clinicopathologic study. Cancer 1965;18:181-192. https://doi.org/10.1002/1097-0142(196502)18:2<181::AID-CNCR2820180209>3.0.CO;2-3
  7. Hwang SH, Lee JH, Kim K, Shin DH, Kim JY, Sol MY, et al. Primary squamous cell carcinoma of the stomach: a case report. Oncol Lett 2014;8:2122-2124. https://doi.org/10.3892/ol.2014.2492
  8. Wakabayashi H, Matsutani T, Fujita I, Kanazawa Y, Nomura T, Hagiwara N, et al. A rare case of primary squamous cell carcinoma of the stomach and a review of the 56 cases reported in Japan. J Gastric Cancer 2014;14:58-62. https://doi.org/10.5230/jgc.2014.14.1.58
  9. Parks RE. Squamous neoplasms of the stomach. Am J Roentgenol Radium Ther Nucl Med 1967;101:447-449. https://doi.org/10.2214/ajr.101.2.447
  10. Callacondo D, Ganoza-Salas A, Anicama-Lima W, Quispe-Mauricio A, Longacre TA. Primary squamous cell carcinoma of the stomach with paraneoplastic leukocytosis: a case report and review of literature. Hum Pathol 2009;40:1494-1498. https://doi.org/10.1016/j.humpath.2009.02.014
  11. Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma. 13th ed. Tokyo: Kanchara, 1999.
  12. Straus R, Heschel S, Fortmann DJ. Primary adenosquamous carcinoma of the stomach. A case report and review. Cancer 1969;24:985-995. https://doi.org/10.1002/1097-0142(196911)24:5<985::AID-CNCR2820240518>3.0.CO;2-4
  13. Muto M, Hasebe T, Muro K, Boku N, Ohtsu A, Fujii T, et al. Primary squamous cell carcinoma of the stomach: a case report with a review of Japanese and Western literature. Hepatogastroenterology 1999;46:3015-3018.
  14. Takita J, Kato H, Miyazaki T, Nakajima M, Fukai Y, Masuda N, et al. Primary squamous cell carcinoma of the stomach: a case report with immunohistochemical and molecular biologic studies. Hepatogastroenterology 2005;52:969-974.
  15. Amuluru K, Gupta H. Primary squamous cell carcinoma of the stomach: a case report. J Gastrointest Cancer 2010;41:24-26. https://doi.org/10.1007/s12029-009-9097-4
  16. Dursun M, Yaldiz M, Isikdogan A, Yilmaz G, Canoruc F, Ormeci N, et al. Primary squamous cell carcinoma of the stomach: a case report and review of the literature. Eur J Gastroenterol Hepatol 2003;15:329-330. https://doi.org/10.1097/00042737-200303000-00018
  17. Sakemi R, So S, Morimitsu Y, Imada H, Ishihara H, Kuhara K, et al. Endoscopic submucosal dissection of squamous cell carcinoma in the upper stomach 5 years after chemoradiotherapy for adenocarcinoma. Clin J Gastroenterol 2014;7:310-315. https://doi.org/10.1007/s12328-014-0503-5
  18. Schwab G, Wetscher G, Dietze O, Schmid K, Pointner R. Primary squamous cell carcinoma of the stomach in a seventeenyear-old boy. Surg Today 1992;22:561-564. https://doi.org/10.1007/BF00308905
  19. Karaca G, Pekcici MR, Ozer H, Koklu S, Kavlakoglu B, Astarci M, et al. Primary squamous cell carcinoma of the stomach in a 68-years-old man. Geriatr Gerontol Int 2011;11:119-120. https://doi.org/10.1111/j.1447-0594.2010.00642.x
  20. Jeong GA, Min YD, Lim SC. Primary squamous cell carcinoma of the stomach that was misdiagnosed as a submucosal tumor. J Korean Surg Soc 2007;73:439-442.
  21. von Waagner W, Wang Z, Picon AI. A rare case of a primary squamous cell carcinoma of the stomach presenting as a submucosal mass. Case Rep Surg 2015;2015:482342.
  22. Hara J, Masuda H, Ishii Y, Aoki N, Nakayama H, Komura K, et al. Exophytic primary squamous cell carcinoma of the stomach. J Gastroenterol 2004;39:299-300. https://doi.org/10.1007/s00535-003-1294-5
  23. Lee JH, Yang KY, Kim BH, Koh SJ, Kang HY, Keam B, et al. A case of exophytic squamous cell carcinoma of the stomach. Korean J Gastrointest Endosc 2006;33:357-360.
  24. Wu XD, Zhou Y, Fan RG, Zhou B, Shi Q, Jia J. Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: a case report. Rev Esp Enferm Dig 2016;108:283-284.
  25. Marubashi S, Yano H, Monden T, Tateishi H, Kanoh T, Iwazawa T, et al. Primary squamous cell carcinoma of the stomach. Gastric Cancer 1999;2:136-141. https://doi.org/10.1007/s101200050036
  26. Modi Y, Shaaban H, Parikh N, Guron G, Maroules M. Primary pure squamous cell carcinoma of the stomach treated with neoadjuvant chemotherapy and surgical resection. Indian J Cancer 2015;52:145. https://doi.org/10.4103/0019-509X.175570
  27. Yanagisawa S, Tsuchiya S, Kaiho T, Togawa A, Shinmura K, Okamoto R, et al. Histological complete response in a case of primary squamous cell carcinoma of the stomach treated by chemotherapy with docetaxel and cisplatin plus 5-fluorouracil. Gan To Kagaku Ryoho 2010;37:307-310.

Cited by

  1. Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach : Case report vol.96, pp.50, 2016, https://doi.org/10.1097/md.0000000000009224
  2. Neuroendocrine carcinoma of the gastric stump: A case report and literature review vol.24, pp.4, 2016, https://doi.org/10.3748/wjg.v24.i4.543
  3. Primary Gastric Squamous Cell Carcinoma vol.10, pp.3, 2016, https://doi.org/10.7759/cureus.2389
  4. Primary gastric squamous cell carcinoma presenting as a large submucosal mass : A case report and literature review vol.99, pp.36, 2016, https://doi.org/10.1097/md.0000000000022125
  5. Primary gastric squamous cell carcinoma with a bilio‐gastric fistula and Krukenberg syndrome vol.9, pp.5, 2016, https://doi.org/10.1002/ccr3.4325
  6. Metachronous squamous cell carcinoma of pancreas and stomach in an elderly female patient: A case report vol.9, pp.31, 2021, https://doi.org/10.12998/wjcc.v9.i31.9680