Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Long-Term Complete Remission of Advanced Gastric Adenocarcinoma with Liver Metastasis

  • Rim, Ch'angbum (Department of Internal Medicine, Eulji University Hospital) ;
  • Lee, Jung-Ae (Department of Internal Medicine, Eulji University Hospital) ;
  • Gong, Soojung (Department of Internal Medicine, Eulji University Hospital) ;
  • Kang, Dong Wook (Department of Pathology, Eulji University Hospital) ;
  • Yang, Heebum (Department of Emergency Medicine, Eulji University Hospital) ;
  • Han, Hyun Young (Department of Radiology, Eulji University Hospital) ;
  • Kim, Nae Yu (Department of Internal Medicine, Eulji University Hospital)
  • Received : 2016.03.16
  • Accepted : 2016.04.30
  • Published : 2016.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

We report the case of a patient with gastric adenocarcinoma with multiple liver metastases. This patient showed complete remission for more than 68 months after S-1/cisplatin combination chemotherapy and radical total gastrectomy. The patient, a 63-year-old man, presented with dyspepsia and difficulty in swallowing. Endoscopic findings showed a huge ulcero-infiltrative mass at the lesser curvature of the mid-body, extending to the distal esophagus. Biopsy revealed a poorly differentiated tubular adenocarcinoma. An abdominal computed tomography scan demonstrated multiple hepatic metastases. S-1/cisplatin combination chemotherapy was initiated, and following completion of six cycles of chemotherapy, the gastric masses and hepatic metastatic lesions had disappeared on abdominal computed tomography. Radical total gastrectomy and D2 lymphadenectomy combined with splenectomy were performed. The patient underwent three cycles of S-1/cisplatin combination chemotherapy followed by tegafur-uracil therapy for 1 year. He remained in complete remission for more than 68 months after surgery.

Keywords

References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5-29. https://doi.org/10.3322/caac.21254
  2. Glimelius B, Ekstrom K, Hoffman K, Graf W, Sjoden PO, Haglund U, et al. Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 1997;8:163-168. https://doi.org/10.1023/A:1008243606668
  3. Rosati G, Ferrara D, Manzione L. New perspectives in the treatment of advanced or metastatic gastric cancer. World J Gastroenterol 2009;15:2689-2692. https://doi.org/10.3748/wjg.15.2689
  4. Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 2008;9:215-221. https://doi.org/10.1016/S1470-2045(08)70035-4
  5. Iwahashi M, Nakamori M, Tani M, Yamaue H, Sakaguchi S, Nakamura M, et al. Complete response of highly advanced gastric cancer with peritoneal dissemination after new combined chemotherapy of S-1 and low-dose cisplatin: report of a case. Oncology 2001;61:16-22. https://doi.org/10.1159/000055347
  6. Mitomi H, Kishimoto I, Amemiya A, Kaneda G, Adachi K, Shimoda T, et al. Advanced gastric cancer showing long-term complete remission in response to S-1 monotherapy: two case reports. Cases J 2008;1:405. https://doi.org/10.1186/1757-1626-1-405
  7. Suzuki Y, Kawasaki N, Ishibashi Y, Yanaga K, Kashiwagi H, Koba K, et al. A case of stage IV gastric cancer: long term remmision achieved with S-1 mono chemotherapy. JMAJ 2006:49:219-223.
  8. Kochi M, Fujii M, Kanamori N, Kaiga T, Takahashi T, Kobayashi M, et al. Neoadjuvant chemotherapy with S-1 and CDDP in advanced gastric cancer. J Cancer Res Clin Oncol 2006;132:781-785. https://doi.org/10.1007/s00432-006-0126-4
  9. Satoh S, Hasegawa S, Ozaki N, Okabe H, Watanabe G, Nagayama S, et al. Retrospective analysis of 45 consecutive patients with advanced gastric cancer treated with neoadjuvant chemotherapy using an S-1/CDDP combination. Gastric Cancer 2006;9:129-135. https://doi.org/10.1007/s10120-006-0369-4
  10. Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, et al; ACTS-GC Group. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 2007;357:1810-1820. https://doi.org/10.1056/NEJMoa072252
  11. Tsuburaya A, Yoshida K, Kobayashi M, Yoshino S, Takahashi M, Takiguchi N, et al. Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial. Lancet Oncol 2014;15:886-893. https://doi.org/10.1016/S1470-2045(14)70025-7
  12. Yoon SY, Kim SY, Cho YH, Chung HW, So Y, Lee HM. Hepatic metastases of gastric adenocarcinoma showing metabolic remission on FDG-PET despite an increase in size on CT. Cancer Res Treat 2009;41:100-103. https://doi.org/10.4143/crt.2009.41.2.100

Cited by

  1. A Case of Complete Remission from Advanced Gastric Adenocarcinoma with Synchronous Liver Metastasis in Response to EOX Chemotherapy vol.2018, pp.None, 2016, https://doi.org/10.1155/2018/3954260