Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Hair-growth Promoting Effect of Grateloupia elliptica Via the Activation of Wnt Pathway

참도박의 Wnt 경로 활성화를 통한 모발성장 효과

  • Kang, Jung-Il (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Kim, Sang-Cheol (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Jeon, You-Jin (Faculty of marine Biomedical Sciences, College of Ocean Sciences, Jeju National University) ;
  • Koh, Young-Sang (Department of Microbiology, School of Medicine, Jeju National University) ;
  • Yoo, Eun-Sook (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Kang, Hee-Kyoung (Department of Pharmacology, School of Medicine, Jeju National University)
  • 강정일 (제주대학교 의학전문대학원 약리학교실) ;
  • 김상철 (제주대학교 의학전문대학원 약리학교실) ;
  • 전유진 (제주대학교 해양과학대학 해양의생명과학부) ;
  • 고영상 (제주대학교 의학전문대학원 미생물학교실) ;
  • 유은숙 (제주대학교 의학전문대학원 약리학교실) ;
  • 강희경 (제주대학교 의학전문대학원 약리학교실)
  • Received : 2016.03.04
  • Accepted : 2016.05.13
  • Published : 2016.06.30
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Abstract

Grateloupia elliptica has been reported to have the proliferation effect of dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. In the present study, we examined in vitro and in vivo hair growth-promoting effect of Grateloupia elliptica. When isolated rat vibrissa follicles were treated with extract of G. elliptica, the hair-fiber lengths of the vibrissa follicles significantly increased. Furthermore, the G. elliptica extract accelerated the telogen-angen transition in C57BL/6 mice. To investigate the molecular mechanisms of the G. elliptica extract on the proliferation of DPCs, we examined the activation of $wnt/{\beta}$-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. The G. elliptica extract activated $wnt/{\beta}$-catenin signaling via the increase of ${\beta}$-catenin and phospho-$GSK3{\beta}$. In addition, the G. elliptica extract increased the level of cyclin E and CDK2, while the level of $p27^{kip1}$ was decreased. These results suggest that the the G. elliptica extract may induce hair growth by proliferation of DPCs via cell-cycle progression and the activation of $Wnt/{\beta}$-catenin signaling.

Keywords

References

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