Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Natural Substance MS-10 Improves Women's Health via Regulation of Estrogen Receptor

천연소재 MS-10의 에스트로겐 수용체 조절을 통한 여성건강 증진

  • Noh, Yoo-Hun (Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University) ;
  • Lee, Ji Won (Department of Urology, College of Medicine, Chung-Ang University) ;
  • Park, Jiae (Department of Food Science and Nutrition, College of Natural Science, Dankook University) ;
  • Lee, Sang Hyung (Department of Neurosurgery, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University) ;
  • Lee, Jun Young (Department of Neuropsychiatry, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University) ;
  • Kim, Sung-Su (Department of Food Science and Nutrition, College of Natural Science, Dankook University) ;
  • Park, Kwang-Kyun (Department of Oral Biology, College of Dentistry, Yonsei University) ;
  • Kim, Tae Jin (Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine) ;
  • Myung, Soon-Chul (Department of Urology, College of Medicine, Chung-Ang University) ;
  • Jeong, Yoonhwa (Department of Food Science and Nutrition, College of Natural Science, Dankook University)
  • 노유헌 (중앙대학교 의과대학 해부학교실) ;
  • 이지원 (중앙대학교 의과대학 비뇨기과학교실) ;
  • 박지애 (단국대학교 자연과학대학 식품영양학과) ;
  • 이상형 (서울대학교 의과대학 신경외과학교실) ;
  • 이준영 (서울대학교 의과대학 정신건강의학과교실) ;
  • 김성수 (단국대학교 자연과학대학 식품영양학과) ;
  • 박광균 (연세대학교 치과대학 구강생물학교실) ;
  • 김태진 (성균관대학교 의과대학 분자세포생물학교실) ;
  • 명순철 (중앙대학교 의과대학 비뇨기과학교실) ;
  • 정윤화 (단국대학교 자연과학대학 식품영양학과)
  • Received : 2016.02.04
  • Accepted : 2016.02.17
  • Published : 2016.06.30
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Abstract

In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women's health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman's index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women's health.

엉겅퀴와 타임의 복합추출물인 MS-10이 여성호르몬 수용체를 가역적으로 활성화해 여성갱년기에 감소하는 에스트로겐이 효율적으로 사용될 수 있도록 작용한다는 것이 확인되었다. 12주간의 인체적용시험에서 MS-10은 안면홍조 및 야한증, 감각마비, 수면장애, 신경과민, 우울, 현기증, 피로, 관절 및 근육통, 두통, 가슴 두근거림(심계항진), 그리고 질건조 등의 여성갱년기 증상이 개선되었음이 확인되었다. 이러한 MS-10의 여성갱년기 증상 개선은 MS-10에 의한 insulin-like growth factor-1의 개선에 기인한 것으로 판단된다. MS-10은 여성갱년기 증상을 개선하는 천연소재 건강 기능식품으로 사용될 수 있다.

Keywords

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