Natural Product Sciences

  • 제22권2호
  • /
  • Pages.129-133
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  • 2016
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production

  • Park, Tae Wook (College of Pharmacy, Chungbuk National University) ;
  • Lee, Chul (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jin Woo (College of Pharmacy, Chungbuk National University) ;
  • Jang, Hari (College of Pharmacy, Chungbuk National University) ;
  • Jin, Qinghao (College of Pharmacy, Chungbuk National University) ;
  • Lee, Mi Kyeong (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
  • 투고 : 2015.12.29
  • 심사 : 2016.01.28
  • 발행 : 2016.06.30
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초록

Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.

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