생체재료학회지 (Biomaterials Research)

  • 제20권4호
  • /
  • Pages.213-221
  • /
  • 2016
  • /
  • 1226-4601(pISSN)
  • /
  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지
DOI QR코드

DOI QR Code

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

  • Bose, Rajendran JC (School of Integrative Engineering, Chung-Ang University) ;
  • Lee, Soo-Hong (Department of Biomedical Science, CHA University) ;
  • Park, Hansoo (School of Integrative Engineering, Chung-Ang University)
  • 투고 : 2016.07.19
  • 심사 : 2016.10.11
  • 발행 : 2016.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

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