The Korean journal of internal medicine

  • 제31권6호
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  • Pages.1018-1029
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  • 2016
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR코드

DOI QR Code

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

  • 투고 : 2015.07.15
  • 심사 : 2015.10.10
  • 발행 : 2016.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

키워드

참고문헌

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피인용 문헌

  1. Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin D vol.13, pp.10, 2016, https://doi.org/10.2903/sp.efsa.2016.en-1078
  2. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality : The Golestan Cohort Study vol.185, pp.8, 2017, https://doi.org/10.1093/aje/kww139
  3. Vascular Calcification: Current Genetics Underlying This Complex Phenomenon vol.130, pp.9, 2016, https://doi.org/10.4103/0366-6999.204931
  4. Vitamin D: Way More Important in Critical Care Than We May Have Recognized vol.37, pp.3, 2016, https://doi.org/10.4037/ccn2017860
  5. Effect of vitamin D deficiency in developed countries vol.122, pp.1, 2016, https://doi.org/10.1093/bmb/ldx005
  6. Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: A Case-control Study vol.36, pp.4, 2016, https://doi.org/10.1515/jomb-2017-0015
  7. Association of the vitamin D receptorFokIgene polymorphism with sex- and non-sex-associated cancers: A meta-analysis vol.39, pp.10, 2016, https://doi.org/10.1177/1010428317727164
  8. Vitamin D and Cardiorespiratory Fitness in the General Population: A Systematic Review vol.87, pp.5, 2016, https://doi.org/10.1024/0300-9831/a000490
  9. Effect of Plasma Level of Vitamin D on Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting vol.33, pp.3, 2018, https://doi.org/10.21470/1678-9741-2017-0214
  10. Cognitive Functioning of Geriatric Patients: Is Hypovitaminosis D the Next Marker of Cognitive Dysfunction and Dementia? vol.10, pp.8, 2016, https://doi.org/10.3390/nu10081104
  11. Vitamin D and calcium kidney stones: a review and a proposal vol.51, pp.1, 2016, https://doi.org/10.1007/s11255-018-1965-z
  12. Vitamin D Deficiency in the Gulf Cooperation Council: Exploring the Triad of Genetic Predisposition, the Gut Microbiome and the Immune System vol.10, pp.None, 2016, https://doi.org/10.3389/fimmu.2019.01042
  13. Vitamin D supplementation alters the expression of genes associated with hypertension and did not induce DNA damage in rats vol.82, pp.4, 2019, https://doi.org/10.1080/15287394.2019.1592044
  14. Serum l-carnitine and vitamin D levels may be low among oral sildenafil citrate non-responders vol.31, pp.2, 2016, https://doi.org/10.1038/s41443-018-0036-4
  15. Dysbiotic gut microbes may contribute to hypertension by limiting vitamin D production vol.42, pp.8, 2016, https://doi.org/10.1002/clc.23195
  16. Efficacy of Vitamin D on Chronic Heart Failure Among Adults : A Meta-analysis of Randomized Controlled Trials vol.90, pp.1, 2016, https://doi.org/10.1024/0300-9831/a000487
  17. Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation vol.26, pp.None, 2016, https://doi.org/10.1177/1076029619899702
  18. Metabolic engineering for the production of fat-soluble vitamins: advances and perspectives vol.104, pp.3, 2016, https://doi.org/10.1007/s00253-019-10157-x
  19. VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/8832478
  20. Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis vol.9, pp.2, 2016, https://doi.org/10.3390/biomedicines9020172
  21. Application of Multifunctional Nanomaterials Combined with Sports Rehabilitation Training in the Diagnosis and Treatment of Cardiovascular Diseases vol.216, pp.1, 2016, https://doi.org/10.1080/10584587.2021.1911260
  22. APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors vol.12, pp.15, 2016, https://doi.org/10.1021/acschemneuro.1c00295
  23. Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population vol.91, pp.5, 2016, https://doi.org/10.1024/0300-9831/a000667