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http://dx.doi.org/10.3904/kjim.2015.224

Vitamin D and its effects on cardiovascular diseases: a comprehensive review  

Perez-Hernandez, Nonanzit (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Aptilon-Duque, Gad (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Nostroza-Hernandez, Maria Cristina (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Vargas-Alarcon, Gilberto (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Rodriguez-Perez, Jose Manuel (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Blachman-Braun, Ruben (Department of Molecular Biology, National Institute of Cardiology "Ignacio Chavez")
Publication Information
The Korean journal of internal medicine / v.31, no.6, 2016 , pp. 1018-1029 More about this Journal
Abstract
Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.
Keywords
Vitamin D; Cardiovascular system; Metabolic networks and pathways;
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