The Korean journal of internal medicine

  • 제31권5호
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  • Pages.971-976
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  • 2016
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Prevalence and possible causes of hypouricemia at a tertiary care hospital

  • Son, Chang-Nam (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Kim, Ji-Min (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Kim, Sang-Hyon (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Cho, Soo-Kyung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Choi, Chan-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Sung, Yoon-Kyoung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Kim, Tae-Hwan (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Bae, Sang-Cheol (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Yoo, Dae-Hyun (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Jun, Jae-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
  • 투고 : 2015.04.30
  • 심사 : 2015.06.25
  • 발행 : 2016.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.

키워드

과제정보

연구 과제 주관 기관 : Hanyang University

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  4. Distribution and Characteristics of Hypouricemia within the Japanese General Population: A Cross-Sectional Study vol.55, pp.3, 2016, https://doi.org/10.3390/medicina55030061
  5. Clinical and Functional Characterization of a Novel URAT1 Dysfunctional Variant in a Pediatric Patient with Renal Hypouricemia vol.9, pp.17, 2016, https://doi.org/10.3390/app9173479
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  7. Effects of uric acid dysregulation on the kidney vol.318, pp.5, 2016, https://doi.org/10.1152/ajprenal.00066.2020
  8. Renal effects of uric acid: hyperuricemia and hypouricemia vol.35, pp.6, 2016, https://doi.org/10.3904/kjim.2020.410
  9. Serum Uric Acid Revealed a U-Shaped Relationship With All-Cause Mortality and Cardiovascular Mortality in High Atherosclerosis Risk Patients: The ASSURE Study vol.8, pp.None, 2016, https://doi.org/10.3389/fcvm.2021.641513
  10. Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970 vol.36, pp.suppl1, 2016, https://doi.org/10.3904/kjim.2020.116