The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Prevalence and possible causes of hypouricemia at a tertiary care hospital

  • Son, Chang-Nam (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Kim, Ji-Min (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Kim, Sang-Hyon (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Cho, Soo-Kyung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Choi, Chan-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Sung, Yoon-Kyoung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Kim, Tae-Hwan (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Bae, Sang-Cheol (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Yoo, Dae-Hyun (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine) ;
  • Jun, Jae-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
  • Received : 2015.04.30
  • Accepted : 2015.06.25
  • Published : 2016.09.01
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Abstract

Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.

Keywords

Acknowledgement

Supported by : Hanyang University

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