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  • 제16권4호
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  • Pages.219-232
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  • 2016
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

  • Yun-Hui Jeon (Department of Biological Sciences, Seoul National University Graduate School) ;
  • Youn Soo Choi (Transplant Research Institute, Department of Medicine, Seoul National University College of Medicine)
  • 투고 : 2016.06.08
  • 심사 : 2016.08.02
  • 발행 : 2016.08.31
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초록

Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B cells predominantly develop. As such, Tfh cells are considered as targets to prevent B cells from producing high affinity antibodies against self-antigens, when high affinity autoantibodies are responsible for immunopathologies in autoimmune disorders. This review article provides an overview of current understanding of Tfh cells and discusses it in the context of animal models of autoimmune diseases and allograft rejections for generation of novel therapeutic interventions.

키워드

과제정보

This work was supported by Research Resettlement Fund for the new faculty of Seoul National University (to YSC) and research grants SNU invitation program for distinguished scholar (to YSC) and SNUH Research Fund (03-2016-0060) (to YSC).

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