IMMUNE NETWORK

The Korean Association of Immunobiologists (대한면역학회)
권호 표지
DOI QR코드

DOI QR Code

Roles of IL-33 in Resistance and Tolerance to Systemic Candida albicans Infections

  • Sang Jun Park (Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan) ;
  • Hong Rae Cho (Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan) ;
  • Byungsuk Kwon (Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan)
  • Received : 2016.03.14
  • Accepted : 2016.04.12
  • Published : 2016.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

IL-33 is a multifunctional cytokine that is released in response to a variety of intrinsic and extrinsic stimuli. The role of IL-33 in Candida albicans infections is just beginning to be revealed. This cytokine has beneficial effects on host defense against systemic C. albicans infections, and it promotes resistance mechanisms by which the immune system eliminates the invading fungal pathogens; and it also elevates host tolerance by reducing the inflammatory response and thereby, potentially, tissue damage. Thus, IL-33 is classified as a cytokine that has evolved functionally to protect the host from damage by pathogens and immunopathology.

Keywords

Acknowledgement

This work was supported by a grant from the National Research Foundation of Korea (funded by the Republic of Korea Ministry of Education, Science, and Technology Grant NRF-2013R1A1A1A01058298).

References

  1. Lionakis, M. S. 2014. New insights into innate immune control of systemic candidiasis. Med. Mycol. 52: 555-564.
  2. Cassone, A. 2013. Development of vaccines for Candida albicans: fighting a skilled transformer. Nat. Rev. Microbiol. 11: 884-891.
  3. Horn, D. L., D. Neofytos, E. J. Anaissie, J. A. Fishman, W. J. Steinbach, A. J. Olyaei, K. A. Marr, M. A. Pfaller, C. H. Chang, and K. M. Webster. 2009. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin. Infect. Dis. 48: 1695-1703.
  4. Medzhitov, R., D. S. Schneider, and M. P. Soares. 2012. Disease tolerance as a defense strategy. Science 335: 936-941.
  5. Schmitz, J., A. Owyang, E. Oldham, Y. Song, E. Murphy, T. K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, D. M. Gorman, J. F. Bazan, and R. A. Kastelein. 2005. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptorrelated protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-490.
  6. Liew, F. Y., N. I. Pitman, and I. B. McInnes. 2010. Diseaseassociated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol. 10: 103-110.
  7. Licona-Limon, P., L. K. Kim, N. W. Palm, and R. A. Flavell. 2013. TH2, allergy and group 2 innate lymphoid cells. Nat. Immunol. 14: 536-542.
  8. Le, H., W. Kim, J. Kim, H. R. Cho, and B. Kwon. 2013. Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies. Front. Immunol. 4: 104.
  9. Sonnenberg, G. F., and D. Artis. 2015. Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat. Med. 21: 698-708.
  10. Villarreal, D. O., M. C. Wise, J. N. Walters, E. L. Reuschel, M. J. Choi, N. Obeng-Adjei, J. Yan, M. P. Morrow, and D. B. Weiner. 2014. Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity. Cancer Res. 74: 1789-1800.
  11. Gao, X., X. Wang, Q. Yang, X. Zhao, W. Wen, G. Li, J. Lu, W. Qin, Y. Qi, F. Xie, J. Jiang, C. Wu, X. Zhang, X. Chen, H. Turnquist, Y. Zhu, and B. Lu. 2015. Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells. J. Immunol. 194: 438-445.
  12. Kim, J., W. Kim, U. J. Moon, H. J. Kim, H. J. Choi, J. I. Sin, N. H. Park, H. R. Cho, and B. Kwon. 2016. Intratumorally establishing type 2 innate lymphoid cells blocks tumor growth. J. Immunol. 196: 2410-2423.
  13. Bonilla, W. V., A. Frohlich, K. Senn, S. Kallert, M. Fernandez, S. Johnson, M. Kreutzfeldt, A. N. Hegazy, C. Schrick, P. G. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Lohning, and D. D. Pinschewer. 2012. The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 335: 984-989.
  14. Schiering, C., T. Krausgruber, A. Chomka, A. Frohlich, K. Adelmann, E. A. Wohlfert, J. Pott, T. Griseri, J. Bollrath, A. N. Hegazy, O. J. Harrison, B. M. Owens, M. Lohning, Y. Belkaid, P. G. Fallon, and F. Powrie. 2014. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 513: 564-568.
  15. Morita, H., K. Arae, H. Unno, K. Miyauchi, S. Toyama, A. Nambu, K. Oboki, T. Ohno, K. Motomura, A. Matsuda, S. Yamaguchi, S. Narushima, N. Kajiwara, M. Iikura, H. Suto, A. N. McKenzie, T. Takahashi, H. Karasuyama, K. Okumura, M. Azuma, K. Moro, C. A. Akdis, S. J. Galli, S. Koyasu, M. Kubo, K. Sudo, H. Saito, K. Matsumoto, and S. Nakae. 2015. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers. Immunity 43: 175-186.
  16. Kolodin, D., P. N. van, C. Li, A. M. Magnuson, D. Cipolletta, C. M. Miller, A. Wagers, R. N. Germain, C. Benoist, and D. Mathis. 2015. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 21: 543-557.
  17. Arpaia, N., J. A. Green, B. Moltedo, A. Arvey, S. Hemmers, S. Yuan, P. M. Treuting, and A. Y. Rudensky. 2015. A distinct function of regulatory T cells in tissue protection. Cell 162: 1078-1089.
  18. Molofsky, A. B., G. F. Van, H. E. Liang, S. J. Van Dyken, J. C. Nussbaum, J. Lee, J. A. Bluestone, and R. M. Locksley. 2015. Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune rerturbation. Immunity 43: 161-174.
  19. Moro, K., H. Kabata, M. Tanabe, S. Koga, N. Takeno, M. Mochizuki, K. Fukunaga, K. Asano, T. Betsuyaku, and S. Koyasu. 2016. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat. Immunol. 17: 76-86.
  20. Duerr, C. U., C. D. McCarthy, B. C. Mindt, M. Rubio, A. P. Meli, J. Pothlichet, M. M. Eva, J. F. Gauchat, S. T. Qureshi, B. D. Mazer, K. L. Mossman, D. Malo, A. M. Gamero, S. M. Vidal, I. L. King, M. Sarfati, and J. H. Fritz. 2016. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat. Immunol. 17: 65-75.
  21. Le, H. T., V. G. Tran, W. Kim, J. Kim, H. R. Cho, and B. Kwon. 2012. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J. Immunol. 189: 287-295.
  22. Alves-Filho, J. C., F. Sonego, F. O. Souto, A. Freitas, W. A. Verri, Jr., M. uxiliadora-Martins, A. Basile-Filho, A. N. McKenzie, D. Xu, F. Q. Cunha, and F. Y. Liew. 2010. Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat. Med. 16: 708-712.
  23. Lionakis, M. S., M. Swamydas, B. G. Fischer, T. S. Plantinga, M. D. Johnson, M. Jaeger, N. M. Green, A. Masedunskas, R. Weigert, C. Mikelis, W. Wan, C. C. Lee, J. K. Lim, A. Rivollier, J. C. Yang, G. M. Laird, R. T. Wheeler, B. D. Alexander, J. R. Perfect, J. L. Gao, B. J. Kullberg, M. G. Netea, and P. M. Murphy. 2013. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J. Clin. Invest 123: 5035-5051.
  24. Ngo, L. Y., S. Kasahara, D. K. Kumasaka, S. E. Knoblaugh, A. Jhingran, and T. M. Hohl. 2014. Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis. J. Infect. Dis. 209: 109-119.
  25. Tran, V. G., H. J. Kim, J. Kim, S. W. Kang, U. J. Moon, H. R. Cho, and B. Kwon. 2015. IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections through Induction of IL- 13 Production by CD4+ T Cells. J. Immunol. 194: 4871-4879.
  26. Coste, A., M. Dubourdeau, M. D. Linas, S. Cassaing, J. C. Lepert, P. Balard, S. Chalmeton, J. Bernad, C. Orfila, J. P. Seguela, and B. Pipy. 2003. PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13. Immunity 19: 329-339.
  27. Gales, A., A. Conduche, J. Bernad, L. Lefevre, D. Olagnier, M. Beraud, G. Martin-Blondel, M. D. Linas, J. Auwerx, A. Coste, and B. Pipy. 2010. PPARgamma controls Dectin-1 expression required for host antifungal defense against Candida albicans. PLoS Pathog. 6: e1000714.
  28. Kim, J., W. Kim, H. T. Le, U. J. Moon, V. G. Tran, H. J. Kim, S. Jung, Q. T. Nguyen, B. S. Kim, J. B. Jun, H. R. Cho, and B. Kwon. 2014. IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2. J. Immunol. 193: 3792-3802.
  29. Majer, O., C. Bourgeois, F. Zwolanek, C. Lassnig, D. Kerjaschki, M. Mack, M. Muller, and K. Kuchler. 2012. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog. 8: e1002811.
  30. Sakai, N., H. L. Van Sweringen, R. C. Quillin, R. Schuster, J. Blanchard, J. M. Burns, A. D. Tevar, M. J. Edwards, and A. B. Lentsch. 2012. Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology 56: 1468-1478.
  31. Monticelli, L. A., G. F. Sonnenberg, M. C. Abt, T. Alenghat, C. G. Ziegler, T. A. Doering, J. M. Angelosanto, B. J. Laidlaw, C. Y. Yang, T. Sathaliyawala, M. Kubota, D. Turner, J. M. Diamond, A. W. Goldrath, D. L. Farber, R. G. Collman, E. J. Wherry, and D. Artis. 2011. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol. 12: 1045-1054.
  32. Kulkarni, O. P., I. Hartter, S. R. Mulay, J. Hagemann, M. N. Darisipudi, V. S. Kumar, S. Romoli, D. Thomasova, M. Ryu, S. Kobold, and H. J. Anders. 2014. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J. Am. Soc. Nephrol. 25: 978-989.
  33. Xu, M. J., D. Feng, H. Wang, Y. Guan, X. Yan, and B. Gao. 2014. IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium. J. Am. Soc. Nephrol. 25: 967-977.
  34. Molofsky, A. B., A. K. Savage, and R. M. Locksley. 2015. Interleukin-33 in tissue homeostasis, injury, and inflammation. Immunity 42: 1005-1019.
  35. McHedlidze, T., M. Waldner, S. Zopf, J. Walker, A. L. Rankin, M. Schuchmann, D. Voehringer, A. N. McKenzie, M. F. Neurath, S. Pflanz, and S. Wirtz. 2013. Interleukin-33- dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39: 357-371.