YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Injectable Sustained Release Gel as a Local Drug Delivery for Periodontal Diseases

치주질환치료를 위한 국소적용 서방출성 리오겔

  • Received : 2016.01.18
  • Accepted : 2016.01.23
  • Published : 2016.02.29
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Abstract

The purpose of this study was the development of sustained-release lyogel of chlorhexidine in the treatment of periodontal diseases. A sustained-release chlorhexidine lyogel (CHX-G) was formulated, based on Eudragit$^{(R)}$ (1~3%), polyvinyl pyrrolidone (PVP) (0~10%), triacetin (20~40%), hydroxy ethyl cellulose (HEC) (1%) and glycerin. In vitro studies were performed to determine the release rate of chlorhexidine from CHX-Gs using dialysis tube. Our results suggest that the release rate of chlorhexidine from lyogel could be controlled by changing the lyogel compositions.

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References

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