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μ-PIV기법을 이용한 동정맥루 모사혈관에서의 모사 혈액의 점도특성에 따른 혈류역학적 분석

Hemodynamical analysis by viscosity characteristics of artificial blood for μ-PIV experiment of Radio-cephalic arteriovenous fistula(RC-AVF)

  • Song, Ryungeun (School of Mechanical Enginnering, Sungkyunkwan University) ;
  • Lee, Jinkee (School of Mechanical Enginnering, Sungkyunkwan University)
  • 투고 : 2016.03.25
  • 심사 : 2016.04.13
  • 발행 : 2016.04.30

초록

Radio-cephalic arteriovenous fistula(RC-AVF) is the most recommended operation of achieving access for hemodialysis. However, it has high rates of early failure depending on the many haemodynamic conditions. To increase RC-AVF patency rate, many researches were performed by in-vitro experiment via artificial vessel and blood analogue fluid, and there were conflicting opinions about whether the non-Newtonian properties of blood have an influence on the flow in large arteries. To investigate the influence of viscoelasticity of blood within the RC-AVF, we fabricated three dimensional artificial RC-AVF and two kinds of blood analogue fluid. The velocity field of two fluids within the vessel were measured by micro-particle velocimetry(m-PIV) and compared with each other. The velocity profiles of both fluids for systolic phase were matched well while those for diastolic phase did not correspond. Therefore, it is desired to use non-newtonian fluid for in-vitro experiment of RC-AVF.

키워드

참고문헌

  1. Hemphill, H. and Allon, M., Konner, K., Work, J., Vassalotti, J. A., 2003, "How can the use of arteriovenous fistulas be increased?" Seminars in Dialysis, Vol.16, No.3, pp.214-216 https://doi.org/10.1046/j.1525-139X.2003.16042_1.x
  2. Jung, Y., Kim, N. and Kim, Y., 1998, "The Relation between Radial Artery, Cephalic Vein Diameter and Early Obstruction of Radiocephalic Arteriovenous Fistula in Hemodialysis Patients," Korean Journal of Vascular and Endovascular
  3. Malec A.M, S.L. Alper, and S. Izumo, 1999, "Hemodynamic shear stress and its role in atherosclerosis", JAMA, Vol.282, No.21, pp.2035-2042. https://doi.org/10.1001/jama.282.21.2035
  4. Bogdan, E. I. and Andrea, R., 2012, "Disturbed flow in radial-cephalic arteriovenous fistulae for haemodialysis: low and oscillating shear stress locates the sites of stenosis," Nephrol Dial Transplant, Vol.27, No.1, pp.358-368. https://doi.org/10.1093/ndt/gfr342
  5. Kim, S., Park, S., Lee, J., 2013, "Hemodynamic simulation of arteriovenous fistulas having different anastomosis angles," The KSME Annual meeting, Vol.2013, No.12, pp.175-175
  6. Jeon, M.. Kim, H.. Suh, S.. Choi, Y.. Lee, H.. Doh, Y.. 2013, "Flow Visualization of Arteriovenous Grafting Using PIV Technique", KSME, Vol.32, No.11, pp.985-990.
  7. Bharadvaj, B.K., Mabon, R.F., Giddens, D.P., 1982a. "Steady flow in a model of the human carotid bifurcation. Part I", Flow visualization. Journal of Biomechanics Vol.15, pp.349-362 https://doi.org/10.1016/0021-9290(82)90057-4
  8. Palmen, D.E.M., Gijsen, F.J.H., van de Vosse, F.N., and Janssen, J.D., 1997. "Diagnosing minor stenoses in carotid artery bifurcation models using the disturbed velocity". Journal of Vascular Investigation Vol.3, No.1, pp.26-41.
  9. Gijsen, F.J.H., Vosse, F.N., Janssen, J.D., 1999, "The influence of the non-Newtonian properties of blood on the flow in lartge arteries: steady flow in a carotid bifurcation model" Journal of Biomechanics Vol.32, No.6, pp.601-608. https://doi.org/10.1016/S0021-9290(99)00015-9
  10. Nguyen, M.T. and Lee, S.W. 2015. "Numerical Study on Blood Flow Dynamics and Wall Mechanics in a Compliant Carotid Bifurcation Model", Journal of the Korean Society of Visualization, Vol.13, No.2, pp.28-32 https://doi.org/10.5407/JKSV.2015.13.2.028
  11. Perktold, K., Peter, R.O., Resch, M., Langs, G., 1991. "Pulsatile nonNewtonian flow in threedimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles", Journal of Biomedical Engineering Vol.13, pp.507-515. https://doi.org/10.1016/0141-5425(91)90100-L
  12. Cho, Y. I., Kensey, R., 1991. "Effects of the non-Newtonian viscosity of blood flows in a diseased arterial vessel. Part 1: Steady flows". Biorheology Vol.28, pp.241-262 https://doi.org/10.3233/BIR-1991-283-415
  13. Rodkiewicz, C.M., Sinha, P., Kennedy, J.S., 1990. "On the application of a constitutive equation for whole human blood", Journal of Biomechanical Engineering Vol.112, pp.198-06. https://doi.org/10.1115/1.2891172
  14. Lillehoj, P.B. and C.M. Ho., 2010. "A long-term, stable hydrophilic poly(dimethylsiloxane) coating for capillary-based pumping", in Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference.
  15. Anastasiou, A. D., A. S. Spyrogianni, K. C. Koskinas, G. D. Giannoglou and S. V. Paras, 2012. "Experimental investigation of the flow of a blood analogue fluid in a replica of a bifurcated small artery." Medical Engineering & Physics Vol.34, No.2, pp.211-218. https://doi.org/10.1016/j.medengphy.2011.07.012
  16. Thielicke, W. S., E.J., 2014. "PIVlab-Towards Userfriendly, Affordable and Accurate Digital Particle Image Velocimetry in MATLAB." Journal of Open Research Software Vol.2 No.1.