Journal of Microbiology and Biotechnology

  • 제26권2호
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  • Pages.309-314
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  • 2016
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells

  • Baik, Ji-Sue (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Mun, Seo-Won (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Kim, Kyoung-Sook (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Park, Shin-Ji (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Yoon, Hyun-Kyoung (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Kim, Dong-Hyun (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) ;
  • Park, Min-Kyu (Department of Clinical Pharmacology & Therapeutics, College of Medicine, Dong-A University) ;
  • Kim, Cheorl-Ho (Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, SungKyunKwan University) ;
  • Lee, Young-Choon (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University)
  • 투고 : 2015.07.29
  • 심사 : 2015.11.12
  • 발행 : 2016.02.28
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초록

We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53. Western blot data revealed that the levels of procaspase-8, -3, and Bcl-2 were downregulated in cordycepin-treated U87MG cells, whereas the levels of Fas, FasL, Bak, cleaved caspase-3, -8, and cleaved PARP were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in U87MG cells. Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor. These results suggest that cordycepin triggered apoptosis in U87MG cells through p38 MAPK activation and inhibition of the Akt survival pathway.

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참고문헌

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