Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Low Dose Effect and Non Monotonic Dose Responses(NMDRs) and its Medical Meaning - Focusing on A New Paradigm of Dose-Response Relationship -

Low Dose Effect와 Non Monotonic Dose Responses(NMDRs) 그리고 의학적 의미 - 용량-반응관계의 새로운 패러다임을 중심으로 -

  • Sung, Angela Dongmin (Dep. of Preventive Medicine, College of Korean Medicine, Sangji University) ;
  • Shin, Jeeyoun (College of Korean Medicine, Sangji University) ;
  • Lee, Seungeun (College of Korean Medicine, Sangji University) ;
  • Park, Songmi (College of Korean Medicine, Sangji University) ;
  • Oh, Yeonji (College of Korean Medicine, Sangji University) ;
  • Lee, Sundong (Dep. of Preventive Medicine, College of Korean Medicine, Sangji University)
  • 성 안젤라동민 (상지대학교 한의과대학 예방의학교실) ;
  • 신지연 (상지대학교 한의과대학) ;
  • 이승은 (상지대학교 한의과대학) ;
  • 박송미 (상지대학교 한의과대학) ;
  • 오연지 (상지대학교 한의과대학) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2016.03.24
  • Accepted : 2016.04.15
  • Published : 2016.04.30
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Abstract

Objectives : The aim was to investigate the characteristics of low dose effect and non monotonic dose responses(NMDRs) and to predict the influence it might have on the health and medicine, traditional Korean medicine. Methods : By investigating recently published major literatures related to low dose effect and NMDRs, the definition, mechanism, major related fields, and the influence on public health and medicine has been categorized and summarized. Results : Although there are still heated debates about the definition of low dose, it implies the biological responses in environmental exposure level and the NDMDRs means the nonlinear relationship between the dose-response in the slope sign change. Also, it implies the new form of the curve showing a U, reverse U shape, and the slop sign constantly changing showing various forms. This mechanism is because the two acceptor shows opposing effects to toxic materials and the affinity is different along with the numerical value that increase and decrease being different. These characteristics generally appear in endocrine disrupters such as bisphenol A, agricultural pesticides, metal, and radiation. The research field in the public health and medical treatment is obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause and phytoestrogen. Conclusions : As a result of discussing implications, NMDRs is a particular effect in low dose and heated debates surround this response, research is being conducted surrounding the field of obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause, and phytoestrogen. More research and interest in needed as it can have a massive influence in the public health and medicine.

Keywords

References

  1. Peter Hoet, Low-dose exposure setting the scene, Katholieke Universiteit Leuven, 2015.
  2. Ronald Melnick, George Lucier, Mary Wolfe, Roxanne Hall, George Stancel, Gail Prins, Michael Gallo, Kenneth Reuhl, Shuk-Mei Ho, Terry Brown, John Moore, Julian Leakey, Joseph Haseman, and Michael Kohn, Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review, Environ Health Perspect, 2002;110(4): 427-431. https://doi.org/10.1289/ehp.02110427
  3. Laura N. Vandenberg, Theo Colborn, Tyrone B. Hayes, Jerrold J. Heindel, David R. Jacobs, Jr. , Duk-Hee Lee, Toshi Shioda, Ana M. Soto, Frederick S. vom Saal, Wade V. Welshons, R. Thomas Zoeller, and John Peterson Myers, Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, Endocrine Reviews, 2012;33(3): 378-455. https://doi.org/10.1210/er.2011-1050
  4. Laura N. Vandenberg, Low-Dose Effects of Hormones and Endocrine Disruptors, Vitamins and Hormones, 2014;94:129-164.
  5. Laura N. Vandenberg, Non-Monotonic Dose Responses in Studies of Endocrine Disrupting Chemicals: Bisphenol A as a Case Study, Dose Response, 2014;12(2):259-276. https://doi.org/10.2203/dose-response.13-020.Vandenberg
  6. 국립환경과학원, 유해화학물질 관리 지침, 국립환경과학원고시, 2009;35.
  7. Duk-Hee Lee, Endocrine disrupting chemicals and environmental diseases, J Korean Med Assoc 2012;55(3):243-249. https://doi.org/10.5124/jkma.2012.55.3.243
  8. Lagarde F, Beausoleil C, Belcher SM, Belzunces LP, Emond C, Guerbet M, Rousselle C. Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment. Environ Health. 2015;14:13. https://doi.org/10.1186/1476-069X-14-13
  9. Conolly RB, Lutz WK. Nonmonotonic doseresponse relationships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol Sci. 2004;77(1):151-7. https://doi.org/10.1093/toxsci/kfh007
  10. Laura N Vandenberg, Shelley Ehrlich, Scott M Belcher, Nira Ben-Jonathan, Dana C Dolinoy, Eric R Hugo, Patricia A Hunt, Retha R Newbold, Beverly S Rubin, Katerine S Saili, Ana M Soto, Hong-Sheng Wang & Frederick S vom Saal, Low dose effects of bisphenol A, Endocrine Disruptors, 2013;1(1):e25078. https://doi.org/10.4161/endo.25078
  11. Katarzyna Kuter, Przemyslaw Nowak, Krystyna Golembiowska, Krystyna Ossowska : Increased Reactive Oxygen Species Production in the Brain After Repeated Low-Dose Pesticide Paraquat Exposure in Rats. A Comparison with Peripheral Tissues Neurochem Res 2010; 35:1121-1130. https://doi.org/10.1007/s11064-010-0163-x
  12. Lee DH, Steffes MW, Sjodin A, Jones RS, Needham LL, Jacobs Jr DR. Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. PLoS One. 2011;6(1):e15977. https://doi.org/10.1371/journal.pone.0015977
  13. Skerfving S, Lofmark L, Lundh T, Mikoczy Z, Stromberg U, Late effects of low blood lead concentrations in children on school performance and cognitive functions, Neurotoxicology. 2015;49:114-120. https://doi.org/10.1016/j.neuro.2015.05.009
  14. Jedrychowski W, Perera FP, Jankowski J, Mrozek-Budzyn D, Mroz E, Flak E, Edwards S, Skarupa A, Lisowska-Miszczyk I. , Very low prenatal exposure to lead and mental development of children in infancy and early childhood: Krakow prospective cohort study, Neuroepidemiology, 2009;32(4):270-278. https://doi.org/10.1159/000203075
  15. Liu J, Chen Y, Gao D, Jing J, Hu Q, Prenatal and postnatal lead exposure and cognitive development of infants followed over the first three years of life: a prospective birth study in the Pearl River Delta region, China, Neurotoxicology, 2014 Sep;44:326-334. https://doi.org/10.1016/j.neuro.2014.07.001
  16. Ferraro PM, Costanzi S, Naticchia A, Sturniolo A, Gambaro G, Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006, BMC Public Health, 2010;10:304. https://doi.org/10.1186/1471-2458-10-304
  17. Kippler M, Tofail F, Hamadani JD, Gardner RM, Grantham-McGregor SM, Bottai M, Vahter M, Early-life cadmium exposure and child development in 5-year-old girls and boys: a cohort study in rural Bangladesh, Environ Health Perspect, 2012;120(10):1462-1468. https://doi.org/10.1289/ehp.1104431
  18. Wallin M, Barregard L, Sallsten G, Lundh T, Karlsson MK, Lorentzon M, Ohlsson C, Mellstrom D, Low-Level Cadmium Exposure Is Associated With Decreased Bone Mineral Density and Increased Risk of Incident Fractures in Elderly Men: The MrOS Sweden Study, J Bone Miner Res. 2015.
  19. Sagiv SK, Thurston SW, Bellinger DC, Amarasiriwardena C, Korrick SA, Prenatal exposure to mercury and fish consumption during pregnancy and attention-deficit/hyperactivity disorder-related behavior in children, Arch Pediatr Adolesc Med, 2012;166(12):1123-1131. https://doi.org/10.1001/archpediatrics.2012.1286
  20. FDA, Fish: What Pregnant Women and Parents Should Know, U.S. Food and Drug Administration, June 2014. http://www.fda.gov/Food/FoodborneIllnessContaminants/Metals/ucm393070.htm
  21. Tsuji JS, Garry MR, Perez V, Chang ET, Lowlevel arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment, Toxicology. 2015;337:91-107. https://doi.org/10.1016/j.tox.2015.09.002
  22. Tsuji JS, Perez V, Garry MR, Alexander DD, Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment, Toxicology. 2014;323:78-94. https://doi.org/10.1016/j.tox.2014.06.008
  23. Ahmed S, Mahabbat-e Khoda S, Rekha RS, Gardner RM, Ameer SS, Moore S, Ekstrom EC, Vahter M, Raqib R, Arsenic-associated oxidative stress, inflammation, and immune disruption in human placenta and cord blood, Environ Health Perspect. 2011;119(2):258-264. https://doi.org/10.1289/ehp.1102086
  24. Kenji Kamiya, Kotaro Ozasa, Suminori Akiba, Ohstura Niwa, Kazunori Kodama, Noboru Takamura, Elena K Zaharieva, Yuko Kimura, Long-term effects of radiation exposure on health, Lancet 2015;386:469-478. https://doi.org/10.1016/S0140-6736(15)61167-9
  25. Kathryn Doyle, Long term low dose radiation exposure may increase leukemia risk, scientific american, 2015. http://www.reuters.com/article/us-health-radiation-leukemia-idUSKCN0PJ2O920150709
  26. National Academy of Sciences, Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII, 2006.
  27. David J. Brenner, Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know, PNAS, 2003;100(24): 13761-13766. https://doi.org/10.1073/pnas.2235592100
  28. National Academy of Sciences, Low Levels Of Ionizing Radiation May Cause Harm, 2005.
  29. 질병관리본부, 제5차 만성질환예방관리 포럼, 2015. http://5032.tistory.com/369.
  30. 이덕희, 호메시스: 건강과 질병의 블랙박스, MID, 2015.
  31. Retha R. Newbold, Elizabeth Padilla-Banks, Ryan J. Snyder, Terry M. Phillips, Wendy N. Jefferson, Developmental exposure to endocrine disruptors and the obesity epidemic, Reprod Toxicol. 2007;23(3):290-296. https://doi.org/10.1016/j.reprotox.2006.12.010
  32. 전희진, 키작은 아이 무조건 호르몬 치료 안돼요, 대전일보, 2016. http://www.daejonilbo.com/news/newsitem.asp?pk_no=1203555.
  33. Susan Hong, Aarati Didwania, Olufunmilayo Olopade, Pamela Ganschow, The Expanding Use of Third-Generation Aromatase Inhibitors: What the General Interest Needs to Know, J Gen Intern Med. 2009;24(2):383-388. https://doi.org/10.1007/s11606-009-1037-2
  34. E Bastiaannet, K Sampieri, O M Dekkers, A J M de Craen, M P P van Herk-Sukel, V Lemmens, C B M van den Broek, J W Coebergh, R M C Herings, C J H van de Velde, R Fodde, G J Liefers, Use of Aspirin postdiagnosis improves survival for colon cancer patients, British Journal of Cancer, 2012;106:1564-1570. https://doi.org/10.1038/bjc.2012.101
  35. 이은지, 어릴수록 혈중 중금속 농축 심각, 미국의 최대 6배, 뉴스1, 2015. http://m.news1.kr/news/category/?detail&2425663&12.
  36. 국립환경연구원, 환경오염의 건강영향 평가를 위한 연구, 2004.
  37. WHO, Ionizing radiation, health effects and protective measures, 2012.
  38. 이재기, 2007년 국제방사선 방호위원회 권고- ICRP 간행물 103, 대한방사선방어학회, 2009.
  39. Evanthia Diamanti-Kandarakis, Jean-Pierre Bourguignon, Linda C. Giudice, Russ Hauser, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, Andrea C. Gore, Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, Endocr Rev. 2009;30(4):293-342. https://doi.org/10.1210/er.2009-0002
  40. Jean-Pastor MJ, Bilan J. des accidents htpatiques medicamenteux recueillis par la pharmacovigilance fransaise. Therapie, 1984; 39:493-500.
  41. Lee sun haeng, Kim Hyung Joong, Lee Eun ju, Chang Gyu Tae, The Review of the Herbal Medicines with Phytoestrogenic Effect, J pediatr Korean Med. 2015;29(2):55-77.
  42. Armanini D., Bonanni G., Palermo M., Palermo M., Reduction of serum testosterone in men by liquirice, NEJM. 1999;341:1158-1160. https://doi.org/10.1056/NEJM199910073411515