Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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아동청소년에서 운동의 항우울 효과와 BDNF와의 관련성에 대한 예비 연구

Association between BDNF and Antidepressant Effects of Exercise in Youth: A Preliminary Study

  • 임유빈 (서울대학교 의과대학 정신과학교실 소아정신분과) ;
  • 김준원 (서울대학교 의과대학 정신과학교실 소아정신분과) ;
  • 홍순범 (서울대학교 의과대학 정신과학교실 소아정신분과) ;
  • 김재원 (서울대학교 의과대학 정신과학교실 소아정신분과)
  • Lim, You Bin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Jun Won (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Hong, Soon-Beom (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
  • 투고 : 2015.12.03
  • 심사 : 2016.03.10
  • 발행 : 2016.03.31
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초록

Objectives: The purpose of this study was to evaluate anti-depressive effects of exercise on child and adolescent and its association with brain derived neurotrophic factor (BDNF). Methods: Twenty nine middle school boys (age $13.3{\pm}0.7$) were divided into two groups, 15 boys for control group and 14 in the experimental group. The control group participated in a regular exercise program, 3 times a week for 15 weeks. During the same period, the experimental group participated in an aerobic exercise program specifically designed to enhance anti-depressive effect of exercise. Serum BDNF level and its performance of each group on the Beck Depression Index (BDI), Children's Depression Inventory (CDI), Screen for Child Anxiety Related Emotional Disorders (SCARED), Aggression Questionnaire (AK-Q), and Stroop task were compared before and after the exercise program. Results: Scores of BDI, CDI, SCARED, and AK-Q were significantly lower in both groups after the exercise programs compared to those before the programs. The Stroop task performances were significantly improved after the programs. However, there were no significant differences between two exercise programs, except SCARED separation anxiety, AK-Q physical, and verbal aggression scores. Also, no association was found between serum BDNF level and anti-depressive effects of exercise. Conclusion: Our preliminary results suggest a possible effect of exercise on depression, anxiety, aggression, and cognition of child and adolescents.

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참고문헌

  1. Birmaher B, Brent D; AACAP Work Group on Quality Issues, Bernet W, Bukstein O, Walter H, et al. Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. J Am Acad Child Adolesc Psychiatry 2007;46:1503-1526. https://doi.org/10.1097/chi.0b013e318145ae1c
  2. North TC, McCullagh P, Tran ZV. Effect of exercise on depression. Exerc Sport Sci Rev 1990;18:379-415.
  3. Strohle A. Physical activity, exercise, depression and anxiety disorders. J Neural Transm (Vienna) 2009;116:777-784. https://doi.org/10.1007/s00702-008-0092-x
  4. Yanagisawa H, Dan I, Tsuzuki D, Kato M, Okamoto M, Kyutoku Y, et al. Acute moderate exercise elicits increased dorsolateral prefrontal activation and improves cognitive performance with Stroop test. Neuroimage 2010;50:1702-1710. https://doi.org/10.1016/j.neuroimage.2009.12.023
  5. Wagner M, McBride RE, Crouse SF. The effects of weight-training exercise on aggression variables in adult male inmates. Prison J 1999;79:72-89. https://doi.org/10.1177/0032885599079001005
  6. Brown HE, Pearson N, Braithwaite RE, Brown WJ, Biddle SJ. Physical activity interventions and depression in children and adolescents: a systematic review and meta-analysis. Sports Med 2013;43:195-206. https://doi.org/10.1007/s40279-012-0015-8
  7. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A, et al. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 2010;11:763-773. https://doi.org/10.3109/15622971003611319
  8. Zheng H, Liu Y, Li W, Yang B, Chen D, Wang X, et al. Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behav Brain Res 2006;168:47-55. https://doi.org/10.1016/j.bbr.2005.10.007
  9. Oxenkrug G. Serotonin-kynurenine hypothesis of depression: historical overview and recent developments. Curr Drug Targets 2013; 14:514-521. https://doi.org/10.2174/1389450111314050002
  10. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007;10:1089-1093. https://doi.org/10.1038/nn1971
  11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257-269. https://doi.org/10.1016/S0092-8674(03)00035-7
  12. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 2003;23:6690-6694. https://doi.org/10.1523/JNEUROSCI.23-17-06690.2003
  13. Pozzo-Miller LD, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R, et al. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci 1999;19:4972-4983. https://doi.org/10.1523/JNEUROSCI.19-12-04972.1999
  14. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997;36:980-988. https://doi.org/10.1097/00004583-199707000-00021
  15. Hahn HM, Yum TH, Shin YW, Kim KH, Yoon DJ, Chung KJ. A standardization study of Beck Depression Inventory in Korea. J Korean Neuropsychiatr Assoc 1986;25:487-500.
  16. Cho S, Lee Y. Development of the Korean form of the Kovacs' Children's Depression Inventory. J Korean Neuropsychiatr Assoc 1990;29:943-956.
  17. Birmaher B, Brent DA, Chiappetta L, Bridge J, Monga S, Baugher M. Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry 1999;38:1230-1236. https://doi.org/10.1097/00004583-199910000-00011
  18. Kim MJ. A validation study of the SCARED: for the elementary school upper grades and middle school students. Seoul: The Graduate School of Sookmyung Women's Univ.;2010.
  19. Buss AH, Durkee A. An inventory for assessing different kinds of hostility. J Consult Psychol 1957;21:343-349. https://doi.org/10.1037/h0046900
  20. Buss AH, Perry M. The aggression questionnaire. J Pers Soc Psychol 1992;63:452-459. https://doi.org/10.1037/0022-3514.63.3.452
  21. Kwon SM, Seo SG. Brief report: validation study of the Korean version of the aggression. Korean J Cinic Psychol 2002;186:487-501.
  22. Shin M, Park M. A standardization study for Korean version of the Stroop color-word test children's version. Seoul: The Korean Psychological Association;2006.
  23. Kim YK, Lee HP, Won SD, Park EY, Lee HY, Lee BH, et al. Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:78-85. https://doi.org/10.1016/j.pnpbp.2006.06.024
  24. Daley AJ, Copeland RJ, Wright NP, Roalfe A, Wales JK. Exercise therapy as a treatment for psychopathologic conditions in obese and morbidly obese adolescents: a randomized, controlled trial. Pediatrics 2006;118:2126-2134. https://doi.org/10.1542/peds.2006-1285
  25. Hilyer JC, Wilson DG, Dillon C, Caro L, Jenkins C, Spencer WA, et al. Physical fitness training and counseling as treatment for youthful offenders. J Couns Psychol 1982;29:292-303. https://doi.org/10.1037/0022-0167.29.3.292
  26. MacMahon JR, Gross RT. Physical and psychological effects of aerobic exercise in delinquent adolescent males. Am J Dis Child 1988;142:1361-1366.
  27. Lee SH, Won JY, Kwon JD. The effect of after-school sports participation on youth's psychological variable(depression, aggression, anxiety). Youth Cult publ Forum 2012;31:85-118.
  28. Heidary A, Emami A, Eskandaripour S, Hassani HA, Hasanlu H, Shahbazi M. Effect of exercise on the level of violence (aggression) in the selected male students of wrestling and karate in Zanjan-Iran. Procedia-Soc Behav Sci 2011;30:2416-2417. https://doi.org/10.1016/j.sbspro.2011.10.471
  29. Biddle SJ, Asare M. Physical activity and mental health in children and adolescents: a review of reviews. Br J Sports Med 2011;45:886-895. https://doi.org/10.1136/bjsports-2011-090185
  30. Broman-Fulks JJ, Berman ME, Rabian BA, Webster MJ. Effects of aerobic exercise on anxiety sensitivity. Behav Res Ther 2004;42:125-136. https://doi.org/10.1016/S0005-7967(03)00103-7
  31. Larun L, Nordheim LV, Ekeland E, Hagen KB, Heian F. Exercise in prevention and treatment of anxiety and depression among children and young people. Cochrane Database Syst Rev 2006;19:CD004691.
  32. Lee J, Laurin N, Crosbie J, Ickowicz A, Pathare T, Malone M, et al. Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2007;144B:976-981. https://doi.org/10.1002/ajmg.b.30437
  33. Oades RD, Lasky-Su J, Christiansen H, Faraone SV, Sonuga-Barke EJ, Banaschewski T, et al. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): findings from a family-based association test (FBAT) analysis. Behav Brain Funct 2008;4:48. https://doi.org/10.1186/1744-9081-4-48
  34. Spalletta G, Morris DW, Angelucci F, Rubino IA, Spoletini I, Bria P, et al. BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. Eur Psychiatry 2010;25:311-313.
  35. Yang JS, Yoo SH, Cho SY, Roh HT. Effects of acute soccer game on serum levels of neurotrophins and neurocognitive functions in male adolescents. J Life Sci 2012;22:1444-1450. https://doi.org/10.5352/JLS.2012.22.11.1444
  36. Kim Y. The effect of regular Taekwondo exercise on brain-derived neurotrophic factor and Stroop test in undergraduate student. J Exerc Nutrition Biochem 2015;19:73-79. https://doi.org/10.5717/jenb.2015.15060904
  37. Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med 2010;40:765-801. https://doi.org/10.2165/11534530-000000000-00000
  38. Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 2015;60:56-64. https://doi.org/10.1016/j.jpsychires.2014.10.003

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