한국버섯학회지 (Journal of Mushroom)

  • 제14권4호
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  • Pages.155-161
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  • 2016
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  • 1738-0294(pISSN)
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  • 2288-8853(eISSN)
한국버섯학회 (The Korean Society of Mushroom Science)
권호 표지
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Inhibitory effect of Panax ginseng and Pleurotus osteratus complex on expression of cytokine genes induced by extract of Dermatophagoides pteronissinus in human monocytic THP-1 and EoL-1 cells

  • Park, Kyeong Hun (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Lee, Eun Suk (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Jin, Yong Ik (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration) ;
  • Myung, Kyung Sun (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Park, Hong Woo (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Park, Chun Geon (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA) ;
  • Kong, Won Sik (Mushroom Research Division, National Institute of Horticultural and Herbal Science, RDA) ;
  • Kim, Young Ock (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
  • 투고 : 2016.11.29
  • 심사 : 2016.12.16
  • 발행 : 2016.12.31
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초록

A recent study reported that Pleurotus ostreatus has the potential to be used as a ${\beta}-glucan-based$ cream for supportive complementary therapy of atopic dermatitis. KH054 is a new herbal prescription consisting of P. ostreatus and Panax ginseng. The effects of atopic dermatitis-induced materials on the expression of cytokine genes in human monocytes (THP-1, EoL- 1) have been examined. Some reports demonstrated that P. ginseng augments the activity of natural killer cells, which plays an important role in innate immunity against infection and tumor development. Monocyte chemotactic protein 1 (MCP-1), interleukin (IL)-6, and IL-8 have important roles in mediating the infiltration of various cells into the skin of atopic dermatitis and psoriasis. The present study investigated whether KH054 on induced IL-6, IL-8, and MCP-1 secretion by house dust mite (Dermatophagoides pteronissinus) in THP-1 (human acute monocytic leukemia) and EoL-1(Human eosinophilic leukemia) cell. D. pteronissinus functions in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. The inhibitory effect of KH054 on the induction of IL-6, IL-8, and MCP-1 secretion by D. pteronissinus extract in THP-1 and EoL-1 cells was examined. KH054 potently suppressed the elevated production of IL-6 and IL-8 induced by D. pteronissinus treatment in THP-1 and EoL-1 cells. Based on the present results, KH054 may be useful for developing functional foods to treat atopic dermatitis.

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참고문헌

  1. Ashbee, HR, Fruin A, Ingham E, Holland WJ. 1994. Cunliffe Humoral immunity to Malassezia furfur serovars A, B and C in patients with pityriasis versicolor, seborrhoeic dermatitis and controls. Exp Dermatol. 3: 106-112. https://doi.org/10.1111/j.1600-0625.1994.tb00267.x
  2. Bieber T. 2008. Atopic dermatitis N Engl J Med, 358(14):1483-1494. https://doi.org/10.1056/NEJMra074081
  3. Boxman IL, Ruwhof C, Boerman OC, Lowik, CW, Ponec M. 1996. Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1. Arch dermatol res. 288: 391-398.' https://doi.org/10.1007/BF02507108
  4. Brandt EB. Sivaprasad U. 2011. Th2 cytokines and atopic cermatitis. J Clin Cell Immunol. 10: doi:10.4172/2155-9899.1000110
  5. Furukawa H, Nakamura K, Zheng X, Tojo M, Oyama N, Akiba H. 2004. Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis J Dermatol Sci. 35:35-42 https://doi.org/10.1016/j.jdermsci.2004.02.008
  6. Gabay, C. 2006. Interleukin-6 and chronic inflammation. Arthritis res therapy. 8: S3
  7. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills TAE. 1989. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp.). J aller clinl Immunol. 83: 1055-1067. https://doi.org/10.1016/0091-6749(89)90447-8
  8. Jesenak M, Urbancek S, Majtan J, Banovcin, P, Hercogova, J. 2016. ${\beta}$-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatol Treat. 27: 351-354. https://doi.org/10.3109/09546634.2015.1117565
  9. Jiang Y, Russell TR, Graves DT, Cheng H, Nong SH, Levitz SM. 1996. Monocyte chemoattractant protein 1 and interleukin-8 production in mononuclear cells stimulated by oral microorganisms. Infect immunity. 64: 4450-4455.
  10. Kim JY, Germolec DR, Luster MI. 1990. Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol immunotoxicol. 12: 257-276. https://doi.org/10.3109/08923979009019672
  11. Kim IS, Song GY, Kim DH, Cho SH, Yun CY, Lee JS. 2012. Effect of (E)-2-(3,4-dimethoxyphenyl)-4-oxo-4H-chrom-en-7yl-3-(3,4dimethoxyphenyl) acrylate on the development of atopic dermatitislike lesions. Life Sci. 91: 338344.
  12. Murphy PM, Baggiolini, M, Charo IF, Hebert, CA, Horuk,R, Matsushima K, Oppenheim JJ, Power CA. 2000. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol rev. 52: 145-176.
  13. Le JM, Vilcek J. 1989. Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Laboratory investigation; j technic meth pathol. 61: 588.
  14. Lee JS, Kim IS, Ryu, JS, Yun, CY. 2008. House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. Cytokine. 42: 365-371. https://doi.org/10.1016/j.cyto.2008.03.010
  15. Lee JS, Kim IS, Ryu JS, Kim JH, Kim JS, Kim DH, Yun,CY. 2012. The inhibitory effect of Duchesnea chrysantha extract on the development of atopic dermatitislike lesions by regulating IgE and cytokine production in Nc/Nga mice. Phytother Res. 26: 284290.
  16. Liu CF, Chen YL, Chang WT, Shieh, CC, Yu, CK, Reid KBM, Wang JY. 2005. Mite allergen induces nitric oxide production in alveolar macrophage cell lines via CD14/toll-like receptor 4, and is inhibited by surfactant protein D. Clinic Experi Aller. 35: 1615-1624. https://doi.org/10.1111/j.1365-2222.2005.02387.x
  17. Romagnani S. 1994. Lymphokine production by human T cells in disease states. Ann Rev Immunol 12:227-257 https://doi.org/10.1146/annurev.iy.12.040194.001303
  18. Shakoory B, Fitzgerald SM, Lee SA, Chi DS, Krishnaswamy G. 2004. The role of human mast cell-derived cytokines in eosinophil biology. J interfer cytok res. 24: 271-281. https://doi.org/10.1089/107999004323065057
  19. Smyth MJ, Hayakawa Y, Takeda K, Yagita H. 2002. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer. 2: 850-861. https://doi.org/10.1038/nrc928
  20. Sun XB, Matsumoto T, Kiyohara H, Hirano, M, Yamada H. 1991. Cytoprotective activity of pectic polysaccharides from the root of Panax ginseng. J Ethnopharmacol 31: 101-107. https://doi.org/10.1016/0378-8741(91)90148-7
  21. Voorhorst T, Spieskma FTM, Varekamp, H, Leupen MJ,Lyklema, AW. 1967. The house dust mite (Dermatophagoides pteronyssinus) and the allergens it produces: Identify with the house dust allergen. J Allergy. 39: 325-339. https://doi.org/10.1016/0021-8707(67)90045-7
  22. Yang EJ, Lee JS, Song BB, Yun CY, Kim DH, Kim IS. 2011. Antiinflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice. J Ethnopharmacol . 136: 422-427. https://doi.org/10.1016/j.jep.2010.05.066