Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Self-assembly of Retinoic Acid-conjugated Poly(Amino Acid)'s Derivative

레티노익산이 접목된 폴리아미노산 유도체의 자기조립 현상

  • Han, Sa Ra (Dept. of Chemical Engineering, Soongsil University) ;
  • Lee, Hyeongyeong (Dept. of Chemical Engineering, Soongsil University) ;
  • Kim, Hee-Jin (Dept. of Chemical Engineering, Soongsil University) ;
  • Cho, Yoon Na (Dept. of Chemical Engineering, Soongsil University) ;
  • Lee, Seung-Jun (Dept. of Chemical and Biomolecular Eng., KAIST) ;
  • Zhoh, Choon-Koo (Dept. of Chemical Engineering, Soongsil University) ;
  • Jeong, Jae Hyun (Dept. of Chemical Engineering, Soongsil University)
  • Received : 2016.12.02
  • Accepted : 2016.12.19
  • Published : 2016.12.30
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Abstract

In this study, a poly (amino acid)s derivative grafted with retinoic acids, which could form self-assemblies in an aqueous solution, was successfully synthesized. The synthesized amphiphilic poly (amino acid)s were controlled with 5, 10, 30 mol% substitution of retinoic acid. Then, the amphiphilic poly (amino acid)s were self-assembled by inter/intra molecular stacking of retinoic acids in an aqueous solution. Also, the increasing the degree of substitution (DS) of retinoic acids decreased the size of self-assembled nanoparticles and induced structural transition to bilayer structure from spherical structure. The retinol was stably encapsulated into a core of self-assembled nanoparticle with 10 mol% of DS. This strategy to prepare the self-assemblies of amphiphilic polyaspartamide will serve to improve the efficiency of targeted delivery for a functional cosmetic with various biological modalities.

본 연구에서는 수용액상에서 자기조립 나노입자를 형성할 수 있는 레티노익산이 접목된 양친성 폴리아미노산 유도체를 합성하였다. 합성한 양친성 폴리아미노산은 레티노익산의 접목도가 각각 5, 10, 30 mol%가 되도록 조절하였다. 수용액 상에서 양친성 폴리아미노산은 소수성 레티노익산의 분자 결합에 의해 안정한 자기조립 나노입자를 형성하였다. 자기조립 나노입자는 레티노익산의 접목도가 증가할수록 크기는 작아지고 형태는 구형에서 이중층 구조로 전이되었다. 또한 접목도가 10%일 때, 자기조립 입자의 구조 붕괴 없이 레티놀의 포집 및 전달이 가장 효과적인 것을 확인하였다. 접목도가 제어된 자기조립입자는 레티놀을 안정적으로 포집할 수 있기 때문에 주름개선제 및 다양한 기능성 화장품 전달체로 활용될 수 있다.

Keywords

References

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