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The Antinociceptive Effects of Epidural Tramadol with Bupivacaine in Beagle Dogs

  • Park, Jiyoung (College of Veterinary Medicine.Research institute of Veterinary Medicine, Chungnam National University) ;
  • Kim, Se Hui (College of Veterinary Medicine.Research institute of Veterinary Medicine, Chungnam National University) ;
  • Lee, Hae-Beom (College of Veterinary Medicine.Research institute of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong Mok (College of Veterinary Medicine.Research institute of Veterinary Medicine, Chungnam National University)
  • Received : 2016.02.15
  • Accepted : 2016.12.05
  • Published : 2016.12.30

Abstract

This study investigated the antinociceptive effect of epidural tramadol with bupivacaine in 36 healthy Beagle dogs. The dogs were divided into 6 groups; 1) C (control), 2) B (0.5% bupivacaine 0.1 mL/kg), 3) BT0.5 (0.5% bupivacaine 0.1 mL/kg + tramadol 0.5 mg/kg), 4) BT1 (0.5% bupivacaine 0.1 mL/kg + tramadol 1 mg/kg), 5) BT2 (0.5% bupivacaine 0.1 mL/kg + tramadol 2 mg/kg), 6) BT3 (0.5% bupivacaine 0.1 mL/kg + tramadol 3 mg/kg). The epidural injection was performed under isoflurane inhalation, after then, nociceptive block and motor block scores were assessed with physiologic parameters (HR, RR, RT, MAP). BT groups showed significantly longer antinociceptive time than C and B, while motor block time of BT groups were not different from B except BT3. Durations of total nociceptive block of BT2 ($60.83{\pm}19.08min$) and BT3 ($74.17{\pm}8.61min$) were significantly longer than those of BT0.5 ($33.33{\pm}8.76min$) and BT1 ($37.50{\pm}19.43min$), but there was no significant difference between BT2 and BT3. Durations of total motor block in all groups were less than 20 minutes although that of BT3 was significantly longer than B. There were no significant differences in HR, RR, RT, MAP among groups. Consequently, epidural administration of tramadol (2 mg/kg) with 0.5% bupivacaine (0.1 mL/kg) can be used safely and effectively in dogs.

Keywords

References

  1. Almeida RM, Escobar A, Maguilnik S. Comparison of analgesia provided by lidocaine, lidocaine-morphine or lidocaine-tramadol delivered epidurally in dogs following orchiectomy. Vet Anaesth Analg 2010; 37: 542-549. https://doi.org/10.1111/j.1467-2995.2010.00563.x
  2. Baraka A, Jabbour S, Ghabash M, Nader A, Khoury G, Sibai A. A comparison of epidural tramadol and epidural morphine for postoperative analgesia. Can J Anaesth 1993; 40: 308-313. https://doi.org/10.1007/BF03009627
  3. Barratt SM. Advances in acute pain management. Int Anesthesiol Clin 1997; 35: 27-47. https://doi.org/10.1097/00004311-199703520-00004
  4. Bonica JJ. The need of a taxonomy. Pain 1979; 6: 247-248. https://doi.org/10.1016/0304-3959(79)90046-0
  5. Bunnag N, Durongphongtorn S. Comparison of epidural analgesic efficacy of tramadol-bupivacaine and morphinebupivacaine combinations in dogs subjected to stifle surgery. Thai J Vet Med 2010; 40: 117.
  6. Choudhuri AH, Dharmani P, Kumarl N, Prakash A. Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. Anaesth Intensive Care 2008; 36: 174-179.
  7. Collart L, Luthy C, Dayer P. Multimodal analgesic effect of tramadol. Clin Pharmacol Ther 1993; 53: 223.
  8. Corning JL. Spinal anaesthesia and local medication of the spinal cord. New York Med J 1885; 42: 483-485.
  9. Delilkan AE, Vijayan R. Epidural tramadol for postoperative pain relief. Anaesthesia 1993; 48: 328-331. https://doi.org/10.1111/j.1365-2044.1993.tb06955.x
  10. Driessen B, Reimann W. Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br J Pharmacol 1992; 105: 147-151. https://doi.org/10.1111/j.1476-5381.1992.tb14226.x
  11. Driessen B, Reimann W, Giertz H. Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. Br J Pharmacol 1993; 108: 806-811. https://doi.org/10.1111/j.1476-5381.1993.tb12882.x
  12. Feldman HS, Covino BG. Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog. Anesth Analg 1988; 67: 1047-1052. https://doi.org/10.1213/00000539-198867110-00005
  13. Franquelo C, Toledo A, Manubens J, Cristofol C, Arboix M. Bupivacaine disposition and pharmacologic effects after intravenous and epidural administrations in dogs. Am J Vet Res 1995; 56: 1087-1091.
  14. Hellyer P, Rodan I, Brunt J, Downing R, Hagedorn JE, Robertson SA. AAHA/AAFP pain management guidelines for dogs & cats. J Am Anim Hosp Assoc 2007; 43: 235-248. https://doi.org/10.5326/0430235
  15. Hendrix PK, Raffe MR, Robinson EP, Felice LJ, Randall DA. Epidural administration of bupivacaine, morphine, or their combination for postoperative analgesia in dogs. J Am Vet Med Assoc 1996; 209: 598-607.
  16. Holton L, Reid J, Scott EM, Pawson P, Nolan A. Development of a behaviour-based scale to measure acute pain in dogs. Vet Rec 2001; 148: 525-531. https://doi.org/10.1136/vr.148.17.525
  17. Holton LL, Scott EM, Nolan AM, Reid J, Welsh E. Relationship between physiological factors and clinical pain in dogs scored using a numerical rating scale. J Small Anim Pract 1998; 39: 469-474. https://doi.org/10.1111/j.1748-5827.1998.tb03681.x
  18. Jones RS. Epidural analgesia in the dog and cat. Vet J 2001; 161: 123-131. https://doi.org/10.1053/tvjl.2000.0528
  19. Joshua JO. Epidural anaesthesia. Vet Rec 1956; 68: 801-803.
  20. Laiq N, Khan MN, Tahmeedullah, Gandapur YK, Khan S. Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children undergoing hypospadias surgery. J Coll Physicians Surg Pak 2009; 19: 678-681.
  21. Logan A. Pain control in small animals. Vet Times 2007; 37: 26-27.
  22. Mathews KA. Pain assessment and general approach to management. Vet Clin North Am Small Anim Pract 2000; 30: 729-755. https://doi.org/10.1016/S0195-5616(08)70004-4
  23. Morton DB, Griffiths PH. Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet Rec 1985; 116: 431-436. https://doi.org/10.1136/vr.116.16.431
  24. Natalini CC, da Silva Polydoro A, Crosignani N. Antinociceptive effects of epidural tramadol administration in dogs as an analgesic technique for experimental stifle surgery. Acta Scientiae Veterinariae 2007; 35: 189-195.
  25. Neves CS, Balan JA, Pereira DR, Stevanin H, Cassu RN. A comparison of extradural tramadol and extradural morphine for postoperative analgesia in female dogs undergoing ovariohysterectomy. Acta Cir Bras 2012; 27: 312-317. https://doi.org/10.1590/S0102-86502012000400006
  26. Prakash S, Tyagi R, Gogia AR, Singh R, Prakash S. Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy. Br J Anaesth 2006; 97: 385-388. https://doi.org/10.1093/bja/ael155
  27. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992; 260: 275-285.
  28. Rawal N. Epidural and spinal agents for postoperative analgesia. Surg Clin North Am 1999; 79: 313-344. https://doi.org/10.1016/S0039-6109(05)70385-6
  29. Senel AC, Akyol A, Dohman D, Solak M. Caudal bupivacaine-tramadol combination for postoperative analgesia in pediatric herniorrhaphy. Acta Anaesthesiol Scand 2001; 45: 786-789. https://doi.org/10.1034/j.1399-6576.2001.045006786.x
  30. Spreull JSA. Accidents associated with anaesthesia. Vet Rec 1958; 70: 981.
  31. Steagall PV, Teixeira Neto FJ, Minto BW, Campagnol D, Correa MA. Evaluation of the isoflurane-sparing effects of lidocaine and fentanyl during surgery in dogs. J Am Vet Med Assoc 2006; 229: 522-527. https://doi.org/10.2460/javma.229.4.522
  32. Torske KE, Dyson DH, Pettifer G. End tidal halothane concentration and postoperative analgesia requirements in dogs: a comparison between intravenous oxymorphone and epidural bupivacaine alone and in combination with oxymorphone. Can Vet J 1998; 39: 361-369.
  33. Torske KE, Dyson DH. Epidural analgesia and anesthesia. Vet Clin North Am Small Anim Pract 2000; 30: 859-874. https://doi.org/10.1016/S0195-5616(08)70011-1
  34. Valverde A, Dyson DH, Mcdonell WN, Pascoe PJ. Use of epidural morphine in the dog for pain relief. Vet Comp Orthop Traumatol 1989; 2: 11-14. https://doi.org/10.1055/s-0038-1633182
  35. Vierck CJ. Extrapolation from the pain research literature to problems of adequate veterinary care. J Am Vet Med Assoc 1976; 168: 510-514.
  36. Wetmore LA, Glowaski MM. Epidural analgesia in veterinary critical care. Clin Tech Small Anim Pract 2000; 15: 177-188. https://doi.org/10.1053/svms.2000.16545
  37. Zaric D, Nydahl PA, Philipson L, Samuelsson L, Heierson A, Axelsson K. The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: a double-blind study. Reg Anesth 1996; 21: 14-25.
  38. Zimmerman M. Physiological mechanisms of pain and its treatment. Klinische Anaesthesiol Intensivether 1986; 32: 1-19.