한국응급구조학회지 (The Korean Journal of Emergency Medical Services)

  • 제20권2호
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  • Pages.7-19
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  • 2016
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  • 1738-1606(pISSN)
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  • 2384-2091(eISSN)
한국응급구조학회 (The Korea Society of Emergency Medical Services)
권호 표지
DOI QR코드

DOI QR Code

급성심근경색 쥐 모델의 심정지 후 조기 저체온 치료가 심폐소생술 결과에 미치는 효과

Early hypothermia improves outcomes of cardiopulmonary resuscitation after cardiac arrest in acute myocardial infarction rat models

  • 박정현 (강원대학교 의학전문대학원 해부학교실) ;
  • 임희경 (강원대학교 의학전문대학원 해부학교실) ;
  • 김지희 (강원대학교 응급구조학과) ;
  • 이영일 (단국대학교 의과대학 해부학교실)
  • Park, Jeong-Hyun (Department of Anatomy, School of Medicine, Kangwon National University) ;
  • Im, Hee-Kyung (Department of Anatomy, School of Medicine, Kangwon National University) ;
  • Kim, Jee-Hee (Department of Emergency Medical Services, Kangwon National University) ;
  • Lee, Young-Il (Department of Anatomy, Medical College, Dankook University)
  • 투고 : 2016.06.19
  • 심사 : 2016.08.10
  • 발행 : 2016.08.31
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초록

연구 목적: 본 연구에서는 심근경색 쥐 모델에서 심장정지를 유발시킨 후 심폐소생술을 수행하는 과정에서 조기 저체온 치료를 적용하여 심장근육의 기능회복과 생존율에 미치는 효과를 조사하고자 하였다. 연구 방법: 본 연구를 위하여 체중 450-550g의 수컷 Sprague Dawley 쥐 10 마리에 개흉을 실시하였다. 왼내림심장동맥을 묶어서 심근경색을 유발시켰다. 왼내림심장동맥을 묶은 후 90분 동안 심실세동을 유도하고, 심폐소생술과 제세동을 실시하였다. 대조군(정상체온군)은 회복과정에 정상체온으로 유지한 군이며, 실험군(저체온군)은 회복과정에 $32^{\circ}C$ 4시간 저체온을 유지한 군이다. 연구 결과: 심박출량, 좌심실박출률, 심근수행지수는 심폐소생술 후 첫 4시간 동안 대조군보다 실험군에서 더 양호하게 나타났다. 실험군의 생존시간은 대조군보다 더 길게 나타났다(p<.050). 결 론: 본 연구를 통하여 조기 저체온 치료의 적용이 급성심근경색의 심폐소생술 후 심장 기능을 개선하는 데 탁월한 효과가 있으며, 치료법의 새로운 기준이 될 것이다.

Purpose: To investigate the effect of early hypothermia on post-resuscitation myocardial recovery and survival time after cardiac arrest and resuscitation in a rat model of myocardial infarction(MI). Methods: Thoracotomies were performed in 10 male Sprague Dawley rats weighing 450-455g. Myocardial infarction was induced by ligation of the left anterior descending coronary artery. Ninety minutes after arterial ligation, ventricular fibrillation was induced, cardiopulmonary resuscitation was subsequently performed before defibrillation was attempted. Animals were randomized to control group and experimental group(acute MI-normothermia)($32^{\circ}C$ for 4 hours). Duration of survival was recorded. Myocardial functions, including cardiac output, left ventricular ejection fraction, and myocardial performance index were measured using echocardiography. Results: Myocardial function was significantly better in hypothermia group than the control group during the first 4 hours post-resuscitation. The survival time of the experimental group was greater than that of the control group(p<.050). Conclusion: This study suggests that early hypothermia can attenuate post-resuscitation myocardial dysfunction after acute myocardial function, and may be a useful strategy in post-resuscitation care.

키워드

참고문헌

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