Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Effect of dietary isoflavones of soybean by-product on estrogen and testosterone levels in mouse

  • Park, Sungkwon (Department of Food Science & Biotechnology, Sejong University) ;
  • Choi, Hojun (Department of Food Science & Biotechnology, Sejong University) ;
  • Seo, Jinyoun (BK21 plus Project Team, College of Pharmacy, Seoul National University) ;
  • Cho, Sangrae (BK21 plus Project Team, College of Pharmacy, Seoul National University) ;
  • Kim, Jungsang (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Hong, Sung Wook (World Institute of Kimchi) ;
  • Park, Changseok (Yecheon Agriculture Technology Center)
  • Received : 2016.09.09
  • Accepted : 2016.11.29
  • Published : 2016.12.31
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Abstract

Boar taint, an unpleasant odor of pork, is associated with two substances including androstenone and skatole. Testosterone is a steroid hormone as well as a strong predictor for androstenone secretion. Isoflavones of soy origin play a role in modulating the metabolism of sex hormones. Although several methods responsible for reducing boar taint are under investigation, the precise mechanism by which isoflavones reduce testosterone has not yet been identified. The objective of the current study was to investigate the effects of isoflavones extracted from a soy by-product on the concentration of serum testosterone in mouse. A total of 24 mice were supplemented with basal diet (control), daidzin plus genistin mix (T1), or isoflavone extracts (T2). After 11 days of treatment, size and weight of testis, as well as the concentration of sex hormones, including testosterone and estrogen, were analyzed. There was no difference in size or weight of testis from mice among control, T1, and T2. Serum testosterone levels were significantly decreased (p < 0.05) both in T1 and T2 when compared with the control group. Furthermore, estrogen concentration in blood was increased (p < 0.05) in T2 (numerically increased in T1) compared with the control group. Taken together, the use of isoflavones extracted from soy by-products would be a plausible strategy for reducing testosterone level, ultimately reducing boar taint without castration of piglets.

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References

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