Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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The Association of Serum Ferritin and Metabolic Syndrome and Metabolic Syndrome Score in Korean Adults

대한민국 성인에서 대사증후군 및 대사증후군 구성요소의 증가와 혈청 Ferritin의 관련성

  • Yoon, Hyun (Department of Biomedical Laboratory Science, Hanlyo University) ;
  • Go, Jae Seong (Department of Radiological Science, Gwangyang Health College) ;
  • Kim, Kang Uk (Department of Radiological Science, Gwangyang Health College) ;
  • Lee, Keon Woo (Department of Radiological Science, Gwangyang Health College)
  • 윤현 (한려대학교 임상병리학과) ;
  • 고재성 (광양보건대학교 방사선과) ;
  • 김광욱 (광양보건대학교 방사선과) ;
  • 이건우 (광양보건대학교 방사선과)
  • Received : 2016.10.14
  • Accepted : 2016.11.14
  • Published : 2016.12.31
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Abstract

This study was conducted to assess the relationship amongst serum ferritin, and metabolic syndrome (MetS) and metabolic syndrome score (MSS) in Korean adults. The data of 16,096 adults (6,840 men as well as 4,916 premenopausal and 4,340 postmenopausal women) aged ${\geq}20years$ in the Korean National Health and Nutrition Examination Survey (KNHANES) between 2010 and 2012 were analyzed. The prevalence rate of MetS was 3,978 (24.7%) (men, 24.6%; premenopausal women, 11.1%; postmenopausal women, 40.3%). The key study results were as follows: First, after the adjustment for relevant variables, the serum ferritin level ($M{\pm}SE$) was significantly higher (p<0.001) in the MetS group (men, $132.25{\pm}1.98ng/mL$; premenopausal women, $39.89{\pm}1.49ng/mL$; postmenopausal women, $73.45{\pm}1.14ng/mL$) than in the non-MetS group (men, $111.08{\pm}1.01ng/mL$; premenopausal women, $32.26{\pm}0.50ng/mL$; postmenopausal women, $63.26{\pm}0.98ng/mL$). Second, the serum ferritin levels increased as MSS increased in all groups (men, premenopausal women, and postmenopausal women) (p<0.001). In conclusion, MetS and MSS increases were positively associated with higher serum ferritin levels.

본 연구는 국가자료인 2010~2012년도 국민건강영양조사 자료를 이용하여 제 2형 당뇨병을 가진 대한민국 20세 이상 성인 16,096명(남성, 6,840명; 폐경 전 여성, 4,916명; 폐경 후 여성, 4,340명)을 대상으로 대사증후군(MetS) 및 대사증후군 위험요소의 증가(MSS)와 혈청 Ferritin수준의 관련성을 평가하고자 실시하였다. 대사증후군의 발생률은 16,096명 중 3,978명으로 24.7%(남성, 24.6%; 폐경 전 여성, 11.1%; 폐경 후 여성, 40.3%)이었다. 본 연구의 주요결과는 첫째, 관련변수를 보정한 후의 결과에서, 혈청 ferritin 수준은 비 대사증후군(남성, $111.08{\pm}1.01ng/mL$; 폐경 전 여성, $32.26{\pm}0.50ng/mL$; 폐경 후 여성, $63.26{\pm}0.98ng/mL$)에 비하여 대사증후군(남성, $132.25{\pm}1.98ng/mL$; 폐경전 여성, $39.89{\pm}1.49ng/mL$; 폐경 후 여성, $73.45{\pm}1.14ng/mL$)에서 유의하게 증가하였다(p<0.001). 둘째, 남성과 폐경 전 및 폐경 후 여성 모두에서, 혈청 ferritin 수준은 대사증후군 위험요소의 증가함에 따라 증가하였다(p<0.001). 결론적으로, 대한민국 성인에서 대사증후군 및 대사증후군 위험요소의 증가는 혈청 ferritin 수준을 증가시킨다.

Keywords

References

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