Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
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Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development

  • Ha, Woo Tae (Dept. of Stem Cell and Regenerative Biology, College of Animal Bioscience and Technology, Konkuk University) ;
  • Jeong, Ha Yeon (Dept. of Animal Resources Development Dairy Science Division, RDA) ;
  • Lee, Seung Yoon (Swine Consulting Group, HanByol Farm Tech) ;
  • Song, Hyuk (Dept. of Stem Cell and Regenerative Biology, College of Animal Bioscience and Technology, Konkuk University)
  • Received : 2016.06.29
  • Accepted : 2016.08.30
  • Published : 2016.09.30
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Abstract

The insulin-like growth factor (IGF) pathway is a key signal transduction pathway involved in cell proliferation, migration, and apoptosis. In dairy cows, IGF family proteins and binding receptors, including their intracellular binding partners, regulate mammary gland development. IGFs and IGF receptor interactions in mammary glands influence the early stages of mammogenesis, i.e., mammary ductal genesis until puberty. The IGF pathway includes three major components, IGFs (such as IGF-I, IGF-II, and insulin), their specific receptors, and their high-affinity binding partners (IGF binding proteins [IGFBPs]; i.e., IGFBP1-6), including specific proteases for each IGFBP. Additionally, IGFs and IGFBP interactions are critical for the bioactivities of various intracellular mechanisms, including cell proliferation, migration, and apoptosis. Notably, the interactions between IGFs and IGFBPs in the IGF pathway have been difficult to characterize during specific stages of bovine mammary gland development. In this review, we aim to describe the role of the interaction between IGFs and IGFBPs in overall mammary gland development in dairy cows.

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References

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