Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Potential prevention effects of Rubus occidentalis seed on UVB-induced MMP-1 production and procollagen degradation in CCD-986sk cells

  • Kim, Dong-Hee (Traditional Korean Medicine Technology Division R&D Department Applied Product Development Team, National Development Institute of Korean Medicine) ;
  • Park, Tae-Soon (Traditional Korean Medicine Technology Division R&D Department Applied Product Development Team, National Development Institute of Korean Medicine) ;
  • Son, Jun-Ho (Traditional Korean Medicine Technology Division R&D Department Applied Product Development Team, National Development Institute of Korean Medicine)
  • Received : 2016.07.06
  • Accepted : 2016.08.31
  • Published : 2016.12.31
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Abstract

UV exposure induces matrix metalloproteinases (MMPs) and extracellular matrix-degrading enzymes expression. We studied the protective effect of Rubus occidentalis seed against UVB-generated skin photoaging using human fibroblast cells (CCD-986sk). We used an ELISA kit to measure the supernatents of procollagen type I and MMP-1 in CCD-986sk cells after they were exposed to UVB irradiation. The CCD-986sk cells that were used with RC-E/E after the UVB irradiation caused higher levels of type I procollagen and lesser levels of MMP-1 compared with the control group. Furthermore, the RC-E/E treated group showed lesser MMP-1 levels and higher procollagen type I levels than the untreated counterpart. Therefore, it can be concluded that Rubus occidentalis seed can prevent from skin photoaging.

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References

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