The Journal of the Korean dental association (대한치과의사협회지)

The Korean Dental Association (대한치과의사협회)
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Application of rhBMP-2 loaded collagen membrane on the buccal plate for ridge preservation: a pilot study in dogs

성견의 발치와 협측골 외측에 적용한 교원질 차단막과 재조합 골형성단백질의 치조제 보존 효과

  • Lim, Hyun-Chang (Department of Periodontology, School of Dentistry, Kyung Hee University) ;
  • Kim, Min-Soo (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Yang, Cheryl (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Lee, Jung-Seok (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University) ;
  • Jung, Ui-Won (Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University)
  • 임현창 (경희대학교 치과대학 치주과학교실) ;
  • 김민수 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 양혜주 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이중석 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Received : 2014.07.25
  • Accepted : 2015.04.01
  • Published : 2015.05.01
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Abstract

Objective: The aim of this study was to determine the effect of multi-layer of a collagen membrane alone or loaded rhBMP-2 on the buccal plate for ridge preservation after tooth extraction. Material and methods: Following bilateral extraction of the maxillary 1st and 3rd premolars in five dogs, rhBMP-2 loaded collagen membrane was applied to the buccal plates at the 1st premolar and collagen membrane only was applied to the buccal plates at the 3rd premolar unilaterally. The collagen membranes applied in the experimental groups were piled into four layers. The corresponding sites of the contralateral side healed naturally. After 3months of healing, the animals were sacrificed. Radiographic and histologic analyses were performed. Results: There was no significant difference in the healing of extraction socket at both 1st and 3rd premolars. In microcomputed tomography, the widths of the residual ridge of the experimental groups were similar with the controls. Histologically, the experimental groups did not exhibit different pattern compared to the controls regardless of the addition of rhBMP-2. Conclusion: Layering of the collagen membrane with or without rhBMP-2 on the buccal plate failed to show the effectiveness in dimensional preservation of the extraction socket.

Keywords

Acknowledgement

Supported by : 보건복지부

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